Investigation of an anti-obesity effect of Ang 1-7 via activation of brown adipocyte

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General medical chemistry
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Mori Jun 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20750011)
• Co-Investigator(Kenkyū-buntansha): 的場 聖明 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10305576) ; 中島 久和 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80363985)
• Research Collaborator: MORIMOTO Hidechika 京都府立医科大学, 大学院医学研究科, 大学院生 ; KAWABE Yasuhiro 京都府立医科大学, 大学院医学研究科, 大学院生 ; Kodo Kazuki 京都府立医科大学, 医学研究科, 助教 (60783397) ; Ikoma Kazuya 京都府立医科大学, 医学研究科, 助教 (50516044)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肥満 / 褐色脂肪細胞 / エネルギー代謝

Outline of Final Research Achievements

We hypothesized that Ang 1-7 has anti-obesity effects mediated via increased formation of brown adipose tissue (BAT) and demonstrated the following findings.
1) Ang 1-7 exerts anti-obesity effects by increasing energy expenditure via brown adipocyte differentiation, 2) Ang 1-7 ameliorates insulin signaling in BAT accompanied with the decreased lipid droplets, the activation of HSL and the deactivation of perilipin through NE, 3) Ang 1-7 upregulates thermogenesis independent of browning in subcutaneous WAT.

Free Research Field

小児代謝内分泌