Roles for monoacylglycerol lipase in lipid homoestasis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08296
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: Kita Yoshihiro 東京大学, 大学院医学系研究科(医学部), 准教授 (20401028)
• Co-Investigator(Renkei-kenkyūsha): TOKUOKA Suzumi. M. 東京大学, 大学院医学系研究科, 特任助教 (60511376) ; HAMANO Fumie 国立研究開発法人国立国際医療研究センター, 上級研究員 (80548511)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 脂質ホメオスタシス / エネルギー代謝 / 肥満

Outline of Final Research Achievements

We evaluated the role(s) for monoacylglycerol lipase (MGL) in energy homeostasis, using MGL- deficient mice and CB1-MGL double-deficient mice. MGL-deficient mice showed delayed intestinal lipid absorption, which was completely CB1-independent, as CB1-MGL deficient mice but not CB1-single deficient mice showed a similar phenotype. Both MGL-deficient mice and CB1-MGL double-deficient mice, but not CB1-single deficient mice showed strong suppression in feeding behavior after lipid gavage. This phenotype was partially rescued by vagotomy, suggesting MGL's role in satiety regulation through gut-brain axis.

Free Research Field

脂質生化学