Tissue-specific function of VDR on colitis and colitic cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAMOTO YOKO 東京大学, 医学部附属病院, 助教 (30376644)
• Co-Investigator(Kenkyū-buntansha): 渡邉 聡明 東京大学, 医学部附属病院, 教授 (80210920)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: VDR / 大腸癌 / 炎症性腸疾患 / ビタミンD / 遺伝子欠損マウス

Outline of Final Research Achievements

The present study investigated biological functions of vitamin D receptor (VDR) on colitis and colitic cancer. Colon epithelium-specific VDRKO mice were generated with CDX2P-CreERT2 transgenic mice and VDR flox mice. Although colon epithelium-specific VDRKO mice with colitic cancer had worse overall survival than control mice with colitic cancer, no differences were observed in colitis or colitic cancer specific phenotypes between colon epithelium-specific VDRKO and control mice, since decreased expression of Vdr gene in colon of control mice treated with DSS or AOM/DSS was observed.

Free Research Field

大腸肛門外科学