Abnormalities of mitotic-kinase-mediated signal transduction and diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: Goto Hidemasa 愛知県がんセンター(研究所), 腫瘍医化学部, 室長 (20393126)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 分裂期キナーゼ / Aurora-A / Plk1 / Ndel1

Outline of Final Research Achievements

Aurora-A and Plk1 are known to be activated in mitosis. Recently, it was reported that these mitotic kinases also function in interphase. Abnormalities of these interphase functions are considered to be related to several diseases, such as cancer or ciliopathy, but the precise mechanisms remain unknown. In this research project, we found that Ndel1 functions upstream of Aurora-A in interphase. Since Ndel1-hypomorphoc mice exhibit ciliopathy-related disorders, these findings shed light on the pathogenesis of ciliopathy.

Free Research Field

生化学、細胞生物学、病態医化学