Genome-wide investigation of gene-gene interactions in HLA-associated ocular diseases

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human genetics
• Research Institution: Yokohama City University
• Principal Investigator: Yasumura Reiko 横浜市立大学, 医学研究科, 客員研究員 (80534362)
• Co-Investigator(Kenkyū-buntansha): 目黒 明 横浜市立大学, 医学研究科, 特任准教授 (60508802) ; 水木 信久 横浜市立大学, 医学研究科, 教授 (90336579)
• Research Collaborator: NANBA Reiko ; SATO Mayuki
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: ベーチェット病 / サルコイドーシス / HLA / 遺伝子間相互作用

Outline of Final Research Achievements

Behcet's disease and sarcoidosis both are HLA-associated ocular diseases. It is well established that Behcet's disease and sarcoidosis are strongly associated with HLA-B*51 allele and some HLA-DRB1 alleles, respectively. Recent studies have reported that gene-gene interactions between HLA risk alleles and other risk genes are observed in HLA-associated diseases, leading to increase the risk of the diseases. In this study, we performed a genome-wide investigation of gene-gene interactions between HLA risk alleles and other genes in Behcet's disease and sarcoidosis. Our genome-wide gene-gene interaction analysis identified several candidate genes which interact with HLA risk alleles of Behcet's disease and sarcoidosis.

Free Research Field

眼科学