2018 Fiscal Year Final Research Report
MicroRNA dysregulation and signal pathway activation in ulcerative colitids-associated carcinogenesis
| Project/Area Number |
15K08354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2019-03-31
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| Keywords | 潰瘍性大腸炎 / 大腸癌 / 炎症発癌 / マイクロRNA |
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| Outline of Final Research Achievements |
It is hypothesized that dysregulation of microRNA (miR) due to chronic inflammation is one of the possible mechanism in ulcerative colitis (UC) -associated carcinogenesis. We analyzed expression levels of several miRs in surgically resected UC-associated neoplasia and sporadic colon cancer tissues. Our study shows that miRs 20a and 93 are gradually upregulated whereas miRs 21 and 93 are downregulated in inflammatory mucosa through dysplasia to invasive cancer in UC. In addition, miR 20a levels are significantly lower in UC-associated cancer than sporadic cancer. The expression levels of such miRs may be promising useful markers in UC patients for estimating an individual risk for the development of colon cancer. Furthermore, those miRs are potential targets for future chemopreventive approaches in the high-risk population of UC-associated carcinogenesis.
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| Free Research Field |
人体病理
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果として，今回検討したmiRの大腸組織内における発現レベルを解析することにより，潰瘍性大腸炎の癌化の早期発見やこれらのmiRをターゲットとした潰瘍性大腸炎の癌化予防のための新たな治療法の開発に寄与する可能性がある．
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