Studies on biological properties of cancer stem cells in malignant mesothelioma

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08370
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Hyogo Medical University
• Principal Investigator: Sato Ayuko 兵庫医科大学, 医学部, 講師 (20419823)
• Co-Investigator(Kenkyū-buntansha): 辻村 亨 兵庫医科大学, 医学部, 教授 (20227408) ; 篠原 義康 兵庫医科大学, 医学部, 助教 (60723509)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 悪性中皮腫

Outline of Final Research Achievements

It is thought that cancer stem cells in malignant mesothelioma, mesothelioma stem cells, are involved in the resistance to treatment of malignant mesothelioma. When reprogramming factors for induced pluripotent stem cells were introduced into mesothelioma cell lines, colony forming cells appeared. The colony forming cells showed increase of spheroid formation, reduction of proliferation, and increase of resistance to an anticancer drug. In addition, in the colony forming cells, a cell adhesion molecule, which was found as a candidate for mesothelioma stem cell related factor by analyses of tumor specimens from recurrent malignant pleural mesothelioma, was more strongly expressed. Since these cells introduced with reprogramming factors showed characteristics as cancer stem cells, they may be useful to develop new diagnosis and therapy targeting mesothelioma stem cells.

Free Research Field

人体病理学