Analysis of cancer stem cell phenotype of apoptosis-resistant breast cancer cells

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08411
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Doshisha Women's College of Liberal Arts
• Principal Investigator: Takahashi Rei 同志社女子大学, 薬学部, 教授 (60144565)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 乳癌 / 癌幹細胞 / アポトーシス / ALDH / 細胞分化

Outline of Final Research Achievements

The subpopulations of the human breast cancer cell line HCC1937 that exhibit resistance to p53-induced apoptosis showed similarities with the breast cancer stem cells in the expression profiles of some breast cancer stem cell-related markers ALDH1A3, Sox-2, and CD44. These apoptosis-resistant cells showed the ability of not only apoptosis-resistance but also reconstruction of cancer cell hierarchy, epithelial-mesenchymal transition, and ductal differentiation. These findings may provide basis of cancer stem cell properties and aid to develop a new therapeutic measure to cancer.

Free Research Field

病理学