2017 Fiscal Year Final Research Report
Autophagy regulation mechanism via reactive persulfide species and its role in antimicrobial host defense
| Project/Area Number |
15K08456
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Bacteriology (including mycology)
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 細菌 / 感染防御 / オートファジー / 活性イオウ分子種 / 硫化水素 |
|---|
| Outline of Final Research Achievements |
To clarify the role of autophagy in antibacterial host defense, we investigated the regulation mechanism of autophagy mediated by reactive persulfide species and protein S-guanylation, and effects of reactive persulfides produced by bacteria. S-Guanylation of bacteria in infected-host cells was found to be involved in bacterial killing by autophagy in host cells, and reactive persulfides produced by bacteria were suggested to suppress S-guanylation-mediated autophagy induction and contribute to its escape from defense mechanism of host cells.
|
| Free Research Field |
細菌学
|
