Novel interaction between virus and host innate immune system

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08517
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Kumamoto University
• Principal Investigator: OSHIUMI HIROYUKI 熊本大学, 大学院生命科学研究部(医), 教授 (50379103)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 自然免疫 / ウイルス

Outline of Final Research Achievements

Viral infection is a serious threat to our life and society. The innate immune system is a first line of deference against viral infection and is also required for the activation of adaptive immune response. We have been studying about the molecular mechanisms underlying the innate immune response during viral infection. We revealed that: 1) DDX60 played a crucial role in RIG-I-dependent and -independent antiviral activities in vivo; 2) Epidermal growth factor receptor (EGFR) mediated phosphorylation of DDX60, thereby attenuating DDX60 antiviral function; 3) The Zyxin protein stabilized the interaction between RIG-I and its adaptor MAVS and promoted RIG-I-mediated type I interferon production; 4) Extracellular vesicles were required for the innate immune response to hepatitis B virus. These findings elucidated novel molecular mechanisms of the innate immune responses against viral infection.

Free Research Field

免疫学