2017 Fiscal Year Final Research Report
Elucidation of T cell homeostasis regulated by KDEL receptor
| Project/Area Number |
15K08518
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Hokkaido University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | T細胞 / 恒常性 |
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| Outline of Final Research Achievements |
This study proposed a new mechanism as a result of research using a mutant mouse line with reduced naive T cells. In addition to survival signals, this study showed that homeostasis of naive T cells requires a cellular stress resolution mechanism that involves the Kdelr1-PP1 pathway (Nat Commun 2015). Moreover, survival signals from T cell receptor positively regulate the cellular stress resolution depending on the affinity of a T cell receptor (Int Immunol 2016).
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| Free Research Field |
免疫学、炎症学、神経免疫学
|
