The role of AIM in immuno-inflammation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08525
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Immunology
• Research Institution: Kyushu University (2016-2017); The University of Tokyo (2015)
• Principal Investigator: SAKATA DAIJI 九州大学, 生体防御医学研究所, 助教 (70456870)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 免疫 / 炎症 / 神経免疫炎症 / 神経変性疾患 / アトピー / アルツハイマー / 痒み

Outline of Final Research Achievements

To clarify the role of AIM (Apoptosis inhibitor of macrophage) in neuroimmuno-inflammation, we established a mouse model of Alzheimer disease (AD). As a model of human AD, we generated APP (amyloid precursor protein) transgenic mice which have 4 different mutations on human APP gene (the mutations are originally seen in some types of human AD patients), and confirmed that those mice have Aβ accumulation in their brain. We expect that those mice should be a strong tool for analyzing roles of AIM in AD pathology.

Free Research Field

免疫学、薬理学、神経免疫学