Relationship between the peripheral neuropathy due to anticancer drugs and vibration sense or nerve conduction velocity in cancer patients

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08675
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pain science
• Research Institution: Oita University
• Principal Investigator: Shirao Kuniaki 大分大学, 医学部, 教授 (10467996)
• Co-Investigator(Kenkyū-buntansha): 佐藤 雄己 大分大学, 医学部, 副薬剤部長 (00570087) ; 久松 靖史 大分大学, 医学部, 病院特任助教 (00609670) ; 緒方 正男 大分大学, 医学部, 講師 (10332892) ; 平島 詳典 大分大学, 医学部, 助教 (60418837) ; 幸野 和洋 大分大学, 医学部, 助教 (80420644) ; 大津 智 大分大学, 医学部, 講師 (80437920) ; 西川 和男 大分大学, 医学部, 病院特任助教 (70636399) ; 小森 梓 大分大学, 医学部, 病院特任助教 (60799295)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 抗がん剤 / 副作用 / しびれ / 音叉検査値 / 神経伝導速度

Outline of Final Research Achievements

From the viewpoint of reducing the side effects or improving treatment outcomes, it is important to clarify the mechanism of development of peripheral neuropathy (numbness) by various anti-cancer drugs, to clarify the predictive factors for expression and to find a coping strategy. Up to now, we have examined the frequency of occurrence of neurotoxicity of anticancer drugs, the extent of neurotoxicitiy, and the amount of drug exposure to neurotoxicity expression in cancer patients. On the basis of these results, we are conducting a prospective study to clarify the relation between the peripheral neuropathy in cancer patients using anticancer drugs and vibration sense or nerve conduction velocity.

Free Research Field

がん薬物療法