Risk assessment of acute pancreatic complication with type II diabetes mellitus by using big medical database.

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K08710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: The University of Tokyo
• Principal Investigator: Koide Daisuke 東京大学, 大学院医学系研究科(医学部), 特任教授 (50313143)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 疫学 / 糖尿病 / 急性膵炎 / 合併症 / データベース / リスク

Outline of Final Research Achievements

In this study, there seems to be a risk of acute pancreatitis in major drugs such as DPP4 inhibitor in diabetes patients who are increasing year by year, and in the current situation where such package inserts have been revised, I studied how much risk of acute pancreatitis it is as background information of Japanese type 2 diabetes patients because there is not enough information about it. I planned to use large-scale databases such as the National Receipt Database (NDB) managed by our government (Insurance Bureau in the Ministry of Health, Labor and Welfare). Diabetes patients are extracted from disease names and drugs used in such large-scale medical database. By analyzing such database, I assessed the risk of complication of acute pancreatitis with type II diabetes mellitus.

Free Research Field

薬剤疫学

Academic Significance and Societal Importance of the Research Achievements

２型糖尿病は代表的な生活習慣病であり、近年患者数もかなり増えてきており、その中で次々と新薬も開発されてきているが、それら新規の薬剤について急性膵炎のリスクが疑われて添付文書も改訂されている。しかし元々これら２型糖尿病については、病態的に膵臓がダメージを受けることから急性膵炎が起こりやすいのではないかということが懸念されており、しかし十分なデータがなかったことから、それらの情報を与える意味で本研究には意義があるものと考えられる。