Longitudinal association of glycemic biomarkers with diabetic complications in the community

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08738
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Kyushu University
• Principal Investigator: Mukai Naoko 九州大学, 医学研究院, 講師 (90596826)
• Co-Investigator(Kenkyū-buntansha): 清原 裕 九州大学, 医学研究院, 教授 (80161602) ; 二宮 利治 九州大学, 医学研究院, 教授 (30571765)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HbA1c / グリコアルブミン / GA/HbA1c比 / 1,5-アンヒドログルシトール / アルツハイマー病

Outline of Final Research Achievements

We examined the association of glycemic biomarkers with the development of Alzheimer’s disease (AD) in an average 4.8-year follow-up study of 1,187 community-dwelling Japanese subjects aged ≧65 years. The age- and sex-adjusted incidence of AD increased significantly with higher the glycated albumin (GA)/HbA1c ratio, and a similar tendency was seen for GA, while no such association was observed for HbA1c and 1,5-AG. After adjusting for potential confounding factors, positive association of the GA/HbA1c ratio with the risk of AD remained significant. Among subjects with normal glucose tolerance, those with high GA/HbA1c ratio had a higher risk of AD than those with low GA/HbA1c ratio, and a similar tendency was found in those with glucose intolerance. Our findings suggest that the GA/HbA1c ratio may be a useful biomarker for predicting incident AD.

Free Research Field

糖尿病学