The synergistic effect of heavy metal exposure and periodontal disease on preterm birth and/or low birth weight

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K08747
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Epidemiology and preventive medicine
• Research Institution: Jichi Medical University
• Principal Investigator: Ikegami Akihiko 自治医科大学, 医学部, 助教 (60748739)
• Co-Investigator(Kenkyū-buntansha): 香山 不二雄 自治医科大学, 医学部, 客員教授 (50177614)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Takahiko 旭川医科大学, 医学部, 教授 (90200998)
• Research Collaborator: MIZUNO Atsuko 自治医科大学, 医学部 (30364532) ; OHTSU Mayumi 自治医科大学, 医学部 (00644238) ; KOBAYASHI Yayoi 国立研究開発法人国立環境研究所, 研究員 (00391102) ; TAKAGI Mai 国立研究開発法人国立環境研究所, 研究員 (40615978) ; FATMI Zafar Aga Khan University
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 重金属 / 歯周病 / 早産 / 低体重児出産

Outline of Final Research Achievements

We estimated the synergistic effect of heavy metal exposure and periodontal disease on preterm birth and/or low birth weight in Japan and Pakistan. Low birth weight was significantly increased by the combination of heavy metal exposure and periodontal disease, it displayed the synergistic effect of negative in pregnancy.
Major important sources of exposure to heavy metals in Pakistan were lead in food and house dust, and arsenic in drinking water.

Free Research Field

疫学