Analysis of mechanisms for suppressing interferon responsiveness by chronic hepatitis B virus infection

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hiroshima University
• Principal Investigator: TSUGE MASATAKA 広島大学, 自然科学研究支援開発センター, 助教 (50448263)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: B型肝炎ウイルス / 遺伝子発現 / インターフェロン

Outline of Final Research Achievements

It is considered that many gene expressions are regulated by hepatitis B virus (HBV) infection and this regulation of gene expressions are different among infected HBV genotypes. Howevere, it has not been clarified the differences of regulation in gene expresions among HBV genotypes. In the present study, I analyzed gene expression profiles using human hepatocytes with or without HBV infection and then I also analyzed the association between HBV related proteins and the regulated genes via HBV infection. By gene expression analysis, it was identified that regulation levels in several gene expressions were different between HBV genotype A and C infection. And further analyses were indicated that transcription of one gene was regulated by HBx and HBs protein and the upregulation of this gene suppressed interferon responsiveness in human hepatocytes.

Free Research Field

消化器内科