Hepatic pathology of patients achieved sustained hepatitis C viral response

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09019
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Osaka City University
• Principal Investigator: TAMORI Akihiro 大阪市立大学, 大学院医学研究科, 准教授 (30291595)
• Co-Investigator(Kenkyū-buntansha): 村上 善基 大阪市立大学, 大学院医学研究科, 准教授 (00397556) ; 榎本 大 大阪市立大学, 大学院医学研究科, 准教授 (20423874) ; 大藤 さとこ 大阪市立大学, 大学院医学研究科, 准教授 (70433290) ; 久保 正二 大阪市立大学, 大学院医学研究科, 准教授 (80221224)
• Co-Investigator(Renkei-kenkyūsha): HOANG Hai 大阪市立大学, 大学院医学研究科, 研究員 (60623246)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: C型肝炎ウイルス / 肝発癌 / SVR

Outline of Final Research Achievements

We examined the pathology in liver after eradication of hepatitis C virus (HCV) by anti-viral therapy. First of all, single nucleotide polymorphisms (SNPs) were analyzed in patients with HCV. Our data suggested that MICA minor genotype was significantly associated with prevalence of hepatocellular carcinoma (HCC) in patients with HCV. On the other hand, there was no significant associated SNPs with HCC in patients achieved sustained viral response by direct acting anti-virals. In patients achieved sustained viral response by interferon-based therapy, histological stagnation of hepatic fibrosis improvement was related to hepatocarcinogenesis. Immunohistochemical analysis showed that activated stellate cells persistently existed in non-cancerous liver tissue. It was speculated that continuously activated stellated cells might played an important role in SVR-HCC, and continuous hepatic fibrosis.

Free Research Field

肝臓学