Establishment of a novel therapeutic strategy for heart failure based on an understanding of metabolic regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Kobe University
• Principal Investigator: Tanaka Hidekazu 神戸大学, 医学研究科, 講師 (20590342)
• Co-Investigator(Kenkyū-buntansha): 杜 隆嗣 神戸大学, 医学研究科, 特命准教授 (50379418)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心不全 / メタボローム解析 / βヒドロキシ酪酸 / 2-アミノ酪酸 / グルタチオン / 糖尿病

Outline of Final Research Achievements

1) A comprehensive quantification of serum metabolites in patients with atrial septal defect revealed that circulating levels of β-hydroxybutyrate (βOHB) and 2-aminobutyric acid (2-AB) reflected hemodynamic changes. We found that βOHB exert cardioprotective effects against oxidative stress. We also revealed that 2-AB modulates glutathione homeostasis. 2) Coexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is known as a significant factor associated with HFpEF. We revealed the impact of overweight on LV longitudinal myocardial systolic function in patients with type II DM.

Free Research Field

循環器内科学