ミトコンドリア酵素ALDH2遺伝子変異と心不全：iPS細胞誘導心筋細胞での検討

2015 Fiscal Year Research-status Report

• Project/Area Number: 15K09084
• Research Institution: Hiroshima University
• Principal Investigator: 木原 康樹 広島大学, 医歯薬保健学研究院(医), 教授 (40214853)
• Co-Investigator(Kenkyū-buntansha): 東 幸仁 広島大学, 原爆放射線医科学研究所, 教授 (40346490)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心不全 / ミトコンドリア / 酸化ストレス / iPS細胞 / アルデヒド脱水素酵素 / 心房細動

Outline of Annual Research Achievements

当初の研究概要:
1)特発性拡張型心筋症患者(DCM)におけるALDH2遺伝子多型と薬剤効果および予後の関係:広島大学病院および関連施設でDCMと診断され、新規に心不全治療を導入される患者を対象とする。ALDH2遺伝子多型を調査すると同時に、RAS 阻害薬の有効性と心事故発生率を3年間に亘り前向きに調査する。2)特発性拡張型心筋症患者(DCM)から得たiPS 誘導心筋細胞を用いた4HNE産生・アポトーシスとALDH2遺伝子多型との関係:CM患者のうち同意が得られた一部対象において、末梢血白血球からiPS細胞を誘導する。同iPS 細胞から再誘導した心筋細胞を用いて、H2O2やアンジオテンシンによる酸化ストレス負荷時の4HNE産生量と心筋細胞アポトーシス誘導量を定量する。アンジオテンシン負荷実験を施行し、ALDH2活性が重大な病態進行因子であることを示す。
平成27年度に新たに判明したこと：
心不全の増悪因子であり同時に心不全によって誘発される代表的な不整脈である心房細動(AF)罹患患者のALDH2 遺伝子多型を調査した。2009年～2013年の間にカテーテルアブレーションを施行したAF患者577例(男性427例、平均年齢61±11歳)とAFを有さない健常者1935例(男性881例、平均年齢36±15歳)でrs671(ALDH2(Glu487Lys))保因割合を調査比較した。仮説に反して、AF例でALDH2マイナーアレルAは少なかった。さらに、孤立性AF例(高血圧、器質的心疾患なし、年齢≦65歳)182例を抽出し、非AFのコントロール914例と同様の比較検討を行ったが、同様の結果が得られた。飲酒量とAFとの関連は以前より報告されているが、今回の検討でも、ALDH2、ADH1BSNP genotypeと飲酒量との関連性が示された。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

既知の情報から推定したALDH2と酸化ストレス、それらの結果としての慢性循環器疾患の発症という構図が、心房細動を対象とすることで否定された。否定されただけではなくそれとは真逆の相関関係が得られた。遺伝子解析上の差異は極めて大きく単なる実験誤差やサンプリングエラーではないため、ALDH2マイナーアレルは日本人も含めアジア人で心血管系に保護的な役割をになっているのかもしれない。

Strategy for Future Research Activity

上記心房細動患者群において、以下のSNPについて網羅的に検索を実施する。
rs28999113:APRT(Adenine phosphoribosyltransferase)　rs1801133:MTHFR(Methylenetrahydrofolate Reductase、rs138687036:G6PD(Glucose-6-Phosphate Dehydrogenase、rs80338943:GJB2 delation(Connexin 26)、rs671:ALDH2(Aldehyde Dehydrogenase)、rs1229984:ADH(Alcohol Dehydrogenase)、rs429358:ApoE4(Apolipoprotein E)、rs7412:ApoE2(ApoE2(Apolipoprotein E)



アルコール心筋症モデル動物を用いて、ALDH2 (Glu487Lys)の心臓特異的強発現を行い、不整脈誘発についてと、酸化ストレスとの関係を実験的に調査する。

Research Products

• [Int'l Joint Research] スタンフォード大学(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: スタンフォード大学
• [Journal Article] Combination of Flow-Mediated Vasodilation and Nitroglycerine-Induced Vasodilation Is More Effective for Prediction of Cardiovascular Events. (2016)
  • Author(s): Kajikawa M, Maruhashi T, Hida E, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N,Kishimoto S, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Higashi Y.
  • Journal Title: Hypertension Volume: 67(5) Pages: 1045-52
  • DOI: 10.1161/HYPERTENSIONAHA.115.06839.
  • Peer Reviewed
• [Journal Article] Prediction of Flow-Limiting Fractional Flow Reserve in Patients With Stable Coronary Artery Disease Based on Quantitative Myocardial Perfusion Imaging. (2016)
  • Author(s): Tanaka H, Takahashi T, Kozono N, Tanakamaru Y, Ohashi N, Yasunobu Y, Tanaka K, Okada T, Kaseda S, Nakanishi T, Kihara Y.
  • Journal Title: Am J Cardiol. Volume: 117(9) Pages: 1417-26
  • DOI: 10.1016/j.amjcard.2016.02.008.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Increased left atrial pressure in non-heart failure patients with subclinical hypothyroidism and atrial fibrillation. (2016)
  • Author(s): Sairaku A, Nakano Y, Uchimura Y, Tokuyama T, Kawazoe H, Watanabe Y, Matsumura H, Kihara Y.
  • Journal Title: Endocr Connect. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Adaptive Servo-Ventilation for Central Sleep Apnea in Heart Failure. (2016)
  • Author(s): Kihara Y, Seino Y, Momomura S; SAVIOR-C investigators.
  • Journal Title: N Engl J Med. Volume: 374(7) Pages: 687-8
  • DOI: 10.1056/NEJMc1515007#SA1.
  • Peer Reviewed
• [Journal Article] Who is the operator, that is the question: a multicentre study of catheter ablation of atrial fibrillation. (2016)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Maeda M, Hirayama H, Hashimoto H, Kihara Y.
  • Journal Title: Europace Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Heart Rate Control With If Inhibitor, Ivabradine, in Japanese Patients With Chronic Heart Failure - A Randomized, Double-Blind, Placebo-Controlled Phase II Study. (2016)
  • Author(s): Tsutsui H, Momomura S, Yamashina A, Ogawa H, Shimokawa H, Kihara Y, Saito Y, Hagiwara N, Ito H, Ako J, Inomata T, Tanaka T, Kawasaki Y; study investigators.
  • Journal Title: Circ J. Volume: 80(3) Pages: 668-76
  • DOI: 10.1253/circj.CJ-15-1112.
  • Peer Reviewed
• [Journal Article] Common Variant Near HEY2 Has a Protective Effect on Ventricular Fibrillation Occurrence in Brugada Syndrome by Regulating the Repolarization Current. (2016)
  • Author(s): Nakano Y, Ochi H, Onohara Y, Toshishige M, Tokuyama T, Matsumura H, Kawazoe H, Tomomori S, Sairaku A, Watanabe Y, Ikenaga H, Motoda C, Suenari K, Hayashida Y, Miki D, Oda N, Kishimoto S, Oda N, Yoshida Y, Tashiro S, Chayama K, Kihara Y.
  • Journal Title: Circ Arrhythm Electrophysiol. Volume: 9(1) Pages: e003436.
  • DOI: 10.1161/CIRCEP.115.003436.
  • Peer Reviewed
• [Journal Article] Association of mitral annular velocity with myocardial ischemia assessed by single-photon emission computed tomograph. (2016)
  • Author(s): Kurisu S, Iwasaki T, Ikenaga H, Watanabe N, Higaki T, Shimonaga T, Ishibashi K, Dohi Y, Hidaka T, Fukuda Y, Kihara Y.
  • Journal Title: Nucl Med Commun. Volume: 37(3) Pages: 278-82
  • DOI: 10.1097/MNM.0000000000000433.
  • Peer Reviewed
• [Journal Article] Prognostic Factors for Survival in Pulmonary Hypertension Due to Left Heart Disease. (2016)
  • Author(s): Yamabe S, Dohi Y, Fujisaki S, Higashi A, Kinoshita H, Sada Y, Hidaka T, Kurisu S, Yamamoto H, Kihara Y.
  • Journal Title: Circ J. Volume: 80(1) Pages: 243-9
  • DOI: 10.1253/circj.CJ-15-0708.
  • Peer Reviewed
• [Journal Article] Reduction of Central Blood Pressure in Response to Oral Glucose Loading Is Blunted in Patients With Diabetes Mellitus. (2016)
  • Author(s): Higaki T, Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Iwasaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: Am J Hypertens. Volume: 29(3) Pages: 357-64
  • DOI: 10.1093/ajh/hpv120.
  • Peer Reviewed
• [Journal Article] Influence of dual antiplatelet therapy on mean platelet volume in patients with coronary artery disease undergoing percutaneous coronary intervention. (2016)
  • Author(s): Higaki T, Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: Heart Vessels. Volume: 31(3) Pages: 269-74
  • DOI: 10.1007/s00380-014-0599-z.
  • Peer Reviewed
• [Journal Article] Data set for volumetric and pathological findings of epicardial adipose tissue. (2015)
  • Author(s): Kitagawa T, Yamamoto H, Sentani K, Takahashi S, Tsushima H, Senoo A, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Data Brief. Volume: 5 Pages: 337-41
  • DOI: 10.1016/j.dib.2015.09.016. eCollection 2015.
  • Peer Reviewed
• [Journal Article] The Potential Role of Inflammation Associated with Interaction between Osteopontin and CD44 in a Case of Pulmonary Tumor Thrombotic Microangiopathy Caused by Breast Cancer. (2015)
  • Author(s): Higashi A, Dohi Y, Uraoka N, Sentani K, Uga S, Kinoshita H, Sada Y, Kitagawa T, Hidaka T, Kurisu S, Yamamoto H, Yasui W, Kihara Y.
  • Journal Title: Intern Med. Volume: 54(22) Pages: 2877-80
  • DOI: 10.2169/internalmedicine.54.4749.
  • Peer Reviewed / Open Access
• [Journal Article] Effect of a Low-Intensity Pulsed Ultrasound Device, SX-1001, on Clinical Symptoms in Buerger Disease With Limb Ischemia. (2015)
  • Author(s): Higashi Y, Azuma N, Takeishi Y, Minamino T, Kihara Y, Node K, Sata M, Fukumoto Y, Origasa H, Matsuo H, Naritomi H, Fujita M, Shimizu W.
  • Journal Title: Int Heart J. Volume: 56(6) Pages: 632-8
  • DOI: 10.1536/ihj.15-191.
  • Peer Reviewed
• [Journal Article] Clinical value of regression of electrocardiographic left ventricular hypertrophy after aortic valve replacement. (2015)
  • Author(s): Yamabe S, Dohi Y, Higashi A, Kinoshita H, Sada Y, Hidaka T, Kurisu S, Shiode N, Kihara Y; HERO (Hiroshima Heart Study Group) Investigators.
  • Journal Title: Heart Vessels. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] The relationship between inflammation and neoangiogenesis of epicardial adipose tissue and coronary atherosclerosis based on computed tomography analysis. (2015)
  • Author(s): Kitagawa T, Yamamoto H, Sentani K, Takahashi S, Tsushima H, Senoo A, Yasui W, Sueda T, Kihara Y.
  • Journal Title: Atherosclerosis. Volume: 243(1) Pages: 293-9
  • DOI: 10.1016/j.atherosclerosis.2015.09.013.
  • Peer Reviewed
• [Journal Article] Do Lower Target Temperatures or Prolonged Cooling Provide Improved Outcomes for Comatose Survivors of Cardiac Arrest Treated With Hypothermia? (2015)
  • Author(s): Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Miura K, Inoue I, Kihara Y.
  • Journal Title: J Am Heart Assoc. Volume: 4(9) Pages: e002123.
  • DOI: 10.1161/JAHA.115.002123.
  • Peer Reviewed
• [Journal Article] Myocardial Injury after Percutaneous Coronary Intervention for In-Stent Restenosis Versus de novo Stenosis. (2015)
  • Author(s): Shimonaga T, Kurisu S, Watanabe N, Ikenaga H, Higaki T, Iwasaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: Intern Med. Volume: 54(18) Pages: 2299-305
  • DOI: 10.2169/internalmedicine.54.5003.
  • Peer Reviewed
• [Journal Article] Reduction in blood pressure improves impaired nitroglycerine-induced vasodilation in patients with essential hypertension. (2015)
  • Author(s): Maruhashi T, Nakashima A, Kishimoto S, Iwamoto A, Kajikawa M, Oda N, Kihara Y, Aibara Y, Noma K, Higashi Y.
  • Journal Title: Hypertens Res. Volume: 38(12) Pages: 862-8
  • DOI: 10.1038/hr.2015.93.
  • Peer Reviewed
• [Journal Article] Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension. (2015)
  • Author(s): Sada Y, Dohi Y, Uga S, Higashi A, Kinoshita H, Kihara Y.
  • Journal Title: Heart Vessels. Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Effects of myocardial perfusion abnormalities on the accuracy of left ventricular volume and ejection fraction measured by thallium-201 gated single-photon emission tomography:comparison with echocardiography as the reference standard. (2015)
  • Author(s): Kurisu S, Iwasaki T, Abe N, Tamura M, Ikenaga H, Watanabe N, Higaki T, Shimonaga T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: Nucl Med Commun. Volume: 36(11) Pages: 1127-33
  • DOI: 10.1097/MNM.0000000000000369.
  • Peer Reviewed
• [Journal Article] Rho-associated kinase activity is an independent predictor of cardiovascular events in acute coronary syndrome. (2015)
  • Author(s): Kajikawa M, Noma K, Nakashima A, Maruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Hidaka T, Kihara Y, Aibara Y, Chayama K, Sasaki S, Kato M, Dote K, Goto C, Liao JK, Higashi Y.
  • Journal Title: Hypertension. Volume: 66(4) Pages: 892-9
  • DOI: 10.1161/HYPERTENSIONAHA.115.05587.
  • Peer Reviewed
• [Journal Article] Association between the Postprandial Glucose Levels and Arterial Stiffness Measured According to the Cardio-ankle Vascular Index in Non-diabetic Subjects. (2015)
  • Author(s): Tsuboi A, Ito C, Fujikawa R, Yamamoto H, Kihara Y.
  • Journal Title: Intern Med. Volume: 54(16) Pages: 1961-9
  • DOI: 10.2169/internalmedicine.54.3596.
  • Peer Reviewed
• [Journal Article] Holter monitoring for the screening of cardiac disease in diabetes mellitus: The non-invasive Holter monitoring observation of new cardiac events in diabetics study. (2015)
  • Author(s): Nakao YM, Ueshima K, Nohara R, Mizunuma Y, Segawa I, Tanaka-Mizuno S, Yasuno S, Nakao K, Hiramori K, Kihara Y.
  • Journal Title: Diab Vasc Dis Res. Volume: 12(6) Pages: 396-404.
  • DOI: 10.1177/1479164115595523.
  • Peer Reviewed
• [Journal Article] Effects of Cardiac Hemodynamics on Agreement in the pH, HCO3- and Lactate Levels between Arterial and Venous Blood Samples in Patients with Known or Suspected Chronic Heart Failure. (2015)
  • Author(s): Kurisu S, Watanabe N, Ikenaga H, Higaki T, Shimonaga T, Iwasaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: Intern Med. Volume: 54(15) Pages: 1841-7
  • DOI: 10.2169/internalmedicine.54.3995.
  • Peer Reviewed
• [Journal Article] Mean platelet volume and left ventricular geometry in patients with aortic valve stenosis. (2015)
  • Author(s): Kurisu S, Higaki T, Ikenaga H, Watanabe N, Shimonaga T, Iwasaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: Clin Exp Hypertens. Volume: 37(8) Pages: 661-5
  • DOI: 10.3109/10641963.2015.1047942.
  • Peer Reviewed
• [Journal Article] Slow-flow phenomenon after Paclitaxel-coated balloon angioplasty: findings from optical coherence tomography and coronary angioscopy. (2015)
  • Author(s): Ikenaga H, Kurisu S, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Journal Title: JACC Cardiovasc Interv. Volume: 8(4) Pages: e59-62
  • DOI: 10.1016/j.jcin.2014.11.016.
  • Peer Reviewed
• [Journal Article] Exercise oscillatory ventilation: ventilation-perfusion abnormality in heart failure. (2015)
  • Author(s): Kisaka T, Rossiter HB, Wasserman K, Kihara Y.
  • Journal Title: Int J Cardiol. Volume: 185 Pages: 55
  • DOI: 10.1016/j.ijcard.2015.03.123.
  • Peer Reviewed
• [Journal Article] Optical Coherence Tomography Findings After Scoring Balloon Dilatation. (2015)
  • Author(s): Ikenaga H, Kurisu S, Kihara Y.
  • Journal Title: Rev Esp Cardiol (Engl Ed). Volume: 68(11) Pages: 1022
  • DOI: 10.1016/j.rec.2014.12.011.
  • Peer Reviewed
• [Journal Article] Radiation dose reduction for coronary artery calcium scoring at 320-detector CT with adaptive iterative dose reduction 3D. (2015)
  • Author(s): Tatsugami F, Higaki T, Fukumoto W, Kaichi Y, Fujioka C, Kiguchi M, Yamamoto H, Kihara Y, Awai K.
  • Journal Title: Int J Cardiovasc Imaging. Volume: 31(5) Pages: 1045-52
  • DOI: 10.1007/s10554-015-0637-7.
  • Peer Reviewed
• [Journal Article] Exogenous nitric oxide inhibits Rho-associated kinase activity in patients with angina pectoris: a randomized controlled trial. (2015)
  • Author(s): Maruhashi T, Noma K, Fujimura N, Kajikawa M, Matsumoto T, Hidaka T, Nakashima A, Kihara Y, Liao JK, Higashi Y.
  • Journal Title: Hypertens Res. Volume: 38(7) Pages: 485-90
  • DOI: 10.1038/hr.2015.24.
  • Peer Reviewed
• [Journal Article] Value of resting echocardiographic findings and dobutamine stress echocardiography for diagnosing myocardial ischemia in patients with suspected angina pectoris. (2015)
  • Author(s): Utsunomiya H, Hidaka T, Masada K, Shimonaga T, Higaki T, Iwasaki T, Mitsuba N, Ishibashi K, Kurisu S, Kihara Y.
  • Journal Title: Echocardiography. Volume: 32(6) Pages: 993-1002
  • DOI: 10.1016/j.jtcvs.2015.03.003.
  • Peer Reviewed
• [Journal Article] Effect of aldosterone-producing adenoma on endothelial function and Rho-associated kinase activity in patients with primary aldosteronism. (2015)
  • Author(s): Matsumoto T, Oki K, Kajikawa M, Nakashima A, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Hidaka T, Kihara Y, Kohno N, Chayama K, Goto C, Aibara Y, Noma K, Liao JK, Higashi Y.
  • Journal Title: Hypertension. Volume: 65(4) Pages: 841-8
  • DOI: 10.1161/HYPERTENSIONAHA.114.05001.
  • Peer Reviewed
• [Journal Article] Altered breathing syndrome in heart failure: newer insights and treatment options. (2015)
  • Author(s): Tomita Y, Kasai T, Kisaka T, Rossiter HB, Kihara Y, Wasserman K, Daida H.
  • Journal Title: Curr Heart Fail Rep. Volume: 12(2) Pages: 158-65
  • DOI: 10.1007/s11897-014-0250-4.
  • Peer Reviewed
• [Journal Article] Adaptive servo-ventilation therapy using an innovative ventilator for patients with chronic heart failure: a real-world, multicenter, retrospective, observational study (SAVIOR-R). (2015)
  • Author(s): Momomura S, Seino Y, Kihara Y, Adachi H, Yasumura Y, Yokoyama H.
  • Journal Title: Heart Vessels. Volume: 30(6) Pages: 805-17
  • DOI: 10.1007/s00380-014-0558-8.
  • Peer Reviewed
• [Journal Article] Effects of the topographical extent of coronary artery ectasia on coronary blood flow in patients with aortic aneurysms. (2015)
  • Author(s): Ikenaga H, Kurisu S, Watanabe N, Shimonaga T, Higaki T, Iwasaki T, Utsunomiya H, Mitsuba N, Ishibashi K, Dohi Y, Imai K, Sueda T, Kihara Y.
  • Journal Title: Heart Vessels. Volume: 30(6) Pages: 712-8
  • DOI: 10.1007/s00380-014-0540-5.
  • Peer Reviewed
• [Journal Article] Development of new risk score for pre-test probability of obstructive coronary artery disease based on coronary CT angiography. (2015)
  • Author(s): Fujimoto S, Kondo T, Yamamoto H, Yokoyama N, Tarutani Y, Takamura K, Urabe Y, Konno K, Nishizaki Y, Shinozaki T, Kihara Y, Daida H, Isshiki T, Takase S.
  • Journal Title: Heart Vessels. Volume: 30(5) Pages: 563-71
  • DOI: 10.1007/s00380-014-0515-6.
  • Peer Reviewed
• [Presentation] Diagnosis and Management of Takotsubo Cardiomyopathy. (2016)
  • Author(s): Kurisu S, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Development of Atrial Fibrillation is a Bad Sign during Anthracycline Chemotherapy. (2016)
  • Author(s): Amioka M, Okada T, Sairaku A, Fujiwara M, Ohhashi N, Kaseda S, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] The Impact of Dexmedetomidine on the Cardiac Electrophysiological Properties in Patients with Paroxysmal Atrial Fibrillation. (2016)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Tokuyama T, Kawazoe H, Matsumura H, Tomomori S, Amioka M, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Malondialdehyde-Modified Low-density Lipoprotein is a Predictor of Coronary Plaque Vulnerability in Patients with Stable Angina. (2016)
  • Author(s): Ikenaga H, Kurisu S, Watanabe N, Higaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Gender Difference in the Influence of Baseline Brachial Artery Diameter on Flow mediated Vasodilation. (2016)
  • Author(s): Maruhashi T, Higashi Y, Matsui S, Kishimoto S, Oda N, Iwamoto A, Kajikawa M, Iwamoto Y, Hidaka T, Nakashima A, Noma K, Takase B, Tomiyama H, Yamashina A, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Vascular Function and Intima media Thickness of Leg Artery in Peripheral Artery Disease. (2016)
  • Author(s): Iwamoto A, Higashi Y, Noma K, Nakashima A, Maruhashi T, Kajikawa M, Oda N, Kishimoto S, Iwamoto Y, Hidaka T, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Why Some Patients Have Lone Severe Tricuspid Regurgitation without Other Valvular Diseases? (2016)
  • Author(s): Itakura K, Hidaka T, Masada K, Kitagawa T, Suenari K, Dohi Y, Fukuda Y, Kurisu S, Nakano Y, Yamamoto H, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Common Variant in PITX2 Contributes to the Pathogenesis of Atrial Fibrillation by Impairing Sinus Node Function. (2016)
  • Author(s): Tomomori S, Nakano Y, Suenari K, Tokuyama T, Sairaku A, Kawazoe H, Matsumura H, Amioka M, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Frequency and Clinical Manifestations of Cardiovascular Complication in IgG4 Related Disease. (2016)
  • Author(s): Yamamoto H, Kitagawa T, Senoo A, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] The Evaluation of Pulmonary Vascular Resistance and Right Ventricular Function by Using Echocardiography. (2016)
  • Author(s): Dohi Y, Uga S, Higashi A, Kinoshita H, Sada Y, Kitagawa T, Hidaka T, Suenari K, Noma K, Fukuda Y, Kurisu S, Nakano Y, Yamamoto H, Higashi Y, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] 多職種カンファレンスを活用した集学的チーム医療の心不全再入院予防効果に関する検討 (2016)
  • Author(s): 中麻紀子, 北川知郎,中山奨,中村マリ子,金井香菜,八陣美佐子,櫻下弘志,永冨珠紀,吉岡徹典,木原康樹
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Usefulness of the Spasm Provocation Test Using a Pressure Wire for the Diagnosis of Vasospastic Angina. (2016)
  • Author(s): Teragawa H, Fujii Y, Uchimura Y, Ueda T, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Extracorporeal Cardiopulmonary Resuscitation in Shockable or Nonshockable Rhythms. (2016)
  • Author(s): Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Nagai M, Yamane A, Kubo Y, Higashihara T, Miyauchi S, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-20 – 2016-03-20
• [Presentation] Predictive Value of Plaque Morphology Assessed by FD-OCT for Microvascular Obstruction after Elective Stent Implantation －The Intracoronary Electrocardiogram Study－. (2016)
  • Author(s): Ikenaga H, Kurisu S, Watanabe N, Higaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-19 – 2016-03-19
• [Presentation] 18F-Sodium Fluoride Positron Emission Tomography for Molecular Imaging of Coronary Atherosclerosis Detected by Computed Tomography. (2016)
  • Author(s): Kitagawa T, Yamamoto H, Senoo A, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-19 – 2016-03-19
• [Presentation] Evaluation of Left Atrial Pressure in Atrial Fibrillation Patients with Stretched Pulmonary Veins and Their Outcomes after Pulmonary Vein Isolation. (2016)
  • Author(s): Suenari K, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Nakano Y, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-19 – 2016-03-19
• [Presentation] Atrioventricular Nodal Remodeling Resulting from Persistent Atrial Fibrillation. (2016)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Tokuyama T, Kawazoe H, Matsumura H, Tomomori S, Amioka M, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-19 – 2016-03-19
• [Presentation] Activated Partial Thromboplastin Time Measured after Overnight Heparin Bridging Helps Heparinization during Ablation of Atrial Fibrillation. (2016)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Tokuyama T, Kawazoe H, Matsumura H, Tomomori S, Amioka M, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-19 – 2016-03-19
• [Presentation] Endothelial Function is Impaired in Subjects with Increased Serum Triglyceride Levels. (2016)
  • Author(s): Kajikawa M, Higashi Y, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-19 – 2016-03-19
• [Presentation] A Common Genetic Variant within SCN10A Modulates DNAMethylation of SCN5A Promoters. (2016)
  • Author(s): Nakano Y, Ochi H, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Suenari K, Onohara Y, Chayama K, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18 – 2016-03-18
• [Presentation] SCN5A H558R Polymorphism Counteracts Effects of SCN5AMutations by Decrease Risk Allele Expression Level. (2016)
  • Author(s): Matsumura H, Nakano Y, Suenari K, Sairaku A, Tokuyama T, Kawazoe H, Tomomori S, Amioka M, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18 – 2016-03-18
• [Presentation] Anatomy Does Matter: The Relationship between Catheter-tissue Contact Force and Anatomical Variations of Left Atrium. (2016)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Tokuyama T, Kawazoe H, Matsumura H, Tomomori S, Amioka M, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18 – 2016-03-18
• [Presentation] Impact of the Left Atrial Morphological Change by Increased Atrial Pressure in Patients with Atrial Fibrillation. (2016)
  • Author(s): Suenari K, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Nakano Y, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18 – 2016-03-18
• [Presentation] Vascular Function and Vascular Structure are Impaired in Patients with Heart Failure with Preserved Ejection Fraction. (2016)
  • Author(s): Kishimoto S, Higashi Y, Oda N, Iwamoto A, Iwamoto Y, Kajikawa M, Maruhashi T, Hidaka T, Nakashima A, Noma K, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18 – 2016-03-18
• [Presentation] Usefulness of Calcium Subtraction Coronary Computed Tomograpahy Angiography: Compared withMyocardial Perfusion Image. (2016)
  • Author(s): Senoo A, Kitagawa T, Watanabe N, Yamamoto H, Kihara Y.
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 宮城県仙台市
  • Year and Date: 2016-03-18 – 2016-03-18
• [Presentation] Extracorporeal Cardiopulmonary Resuscitation for Nonshockable Rhythms. (2015)
  • Author(s): Kagawa E, Dote K, Kato M, Sasaki S, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-10 – 2015-11-10
  • Int'l Joint Research
• [Presentation] Selenium Supplementation Rescues Cardiac Function in Patients With Severe Heart Failure Who are Intractable to Renin-Angiotensin System Inhibitors and β-blockers. (2015)
  • Author(s): Hiraoka Y, Tanabe M, Yamazaki T, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-10 – 2015-11-10
  • Int'l Joint Research
• [Presentation] Transportation Time Does Not Affect Mortality in Patients With Type A Aortic Dissection in a Hospital Without Cardiothoracic Surgery. (2015)
  • Author(s): Susawa H, Mikami S, Takemoto H, Nakao Y, Kobayashi K, Tanaka H, Tanaka K, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-10 – 2015-11-10
  • Int'l Joint Research
• [Presentation] Anatomy Does Matter: The Relationship Between Catheter-Tissue Contact Force and Anatomical Variations of Left Atrium. (2015)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] Association Between Serum Uric Acid Level and Metabolic Syndrome in a Rural Japanese Population. (2015)
  • Author(s): Nakao Y, Mikami S, Takemoto H, Susawa H, Kobayashi K, Tanaka H, Tanaka K, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] Influence of Endothelial Function and Rho-Associated Kinase Activity in Patients With Primary Aldosteronism. (2015)
  • Author(s): Matsumoto T(Hiroshima Univ), Higashi Y, Iwamoto A, Kajikawa M, Oda N, Maruhashi T, Nakashima A, Noma K, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] Poor Left Ventricular Reverse Remodeling in Patients With Systolic Heart Failure and Atrioventricular Block Who Clinically Responded to Cardiac Resynchronization Therapy: A Multicenter Study. (2015)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Hashimoto H, Maeda M, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] SCN5A H558R Polymorphism Counteracts Effects of SCN5A Mutations by Decrease Risk Allele Expression Level. (2015)
  • Author(s): Matsumura H, Nakano Y, Suenari K, Tokuyama T, Sairaku A, Kawazoe H, Tomomori S, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] The Impact of Dexmedetomidine on the Cardiac Electrophysiological Properties in Patients With Paroxysmal Atrial Fibrillation. (2015)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] Who is the Operator, That is the Problem: A Multicenter Study. (2015)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Maeda M, Hashimoto H, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-09 – 2015-11-09
  • Int'l Joint Research
• [Presentation] Cardiac Resynchronization Therapy for Patients With Cardiac Sarcoidosis. (2015)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Maeda M, Hashimoto H, Hirayama H, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-08 – 2015-11-08
  • Int'l Joint Research
• [Presentation] Endothelial Function is Impaired in Relation to Alcohol Consumption in Men in a Large General Population. (2015)
  • Author(s): Oda N, Higashi Y, Kajikawa M, Maruhashi T, Iwamoto A, Kishimoto S, Hidaka T, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-08 – 2015-11-08
  • Int'l Joint Research
• [Presentation] Endothelial Function is Impaired in Subjects With Increased Ratio of Serum Levels of AGEs to Soluble Form of RAGE. (2015)
  • Author(s): Kajikawa M, Higashi Y, Nakashima A, Fujimura N, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Noma K, Takeuchi M, Matsui T, Yamagishi S, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-08 – 2015-11-08
  • Int'l Joint Research
• [Presentation] Increased Triglyceride Levels are Associated With Endothelial Dysfunction: FMD-Japan Registry. (2015)
  • Author(s): Kajikawa M, Higashi Y, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Noma K, Tomiyama T, Takase B, Yamashina A, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-08 – 2015-11-08
  • Int'l Joint Research
• [Presentation] Significance of Inflammation and Neoangiogenesis of Epicardial Adipose Tissue on Coronary Atherosclerosis Based on Computed Tomography Analysis. (2015)
  • Author(s): Kitagawa T, Yamamoto Y, Tsushima H, Senoo A, Sentani K, Yasui W, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-08 – 2015-11-08
  • Int'l Joint Research
• [Presentation] Vascular Function and Vascular Structure are impaired in Patients With Heart Failure With Preserved Ejection Fraction. (2015)
  • Author(s): Kishimoto S, Higashi Y, Noma K, Nakashima A, Hidaka T, Maruhashi T, Kajikawa M, Iwamoto Y, Iwamoto A, Oda N, Aibara Y, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-08 – 2015-11-08
  • Int'l Joint Research
• [Presentation] Blood Transfusion Deteriorate the Prognosis in Targeted Temperature Management After Cardiac Arrest? (2015)
  • Author(s): Kagawa E, Dote K, Kato M, Sasaki S, Kihara Y.
  • Organizer: The 88th Scientific Sessions of the American Heart Association 2015
  • Place of Presentation: Orlando,USA
  • Year and Date: 2015-11-07 – 2015-11-07
  • Int'l Joint Research
• [Presentation] Fish oils, eicosapentaenoic acid and docosahexaenoic acid, attenuate oxidative stress-induced DNA damage in vascular endothelial cells. (2015)
  • Author(s): Sakai C, Ishida M, Kihara Y, Yoshizumi N, Ishida T.
  • Organizer: European Society of Cardiology 2015
  • Place of Presentation: London,GBR.
  • Year and Date: 2015-08-29 – 2015-08-30
  • Int'l Joint Research
• [Presentation] Can Noninvasive Positive Airway Pressure Improve the Prognosis and Functional Capacity of Heart Failure Through the Suppression of Inflammatory Response? (2015)
  • Author(s): Hidaka T, Kihara Y, Yamamoto H, Nakano Y, Kurisu S, Fukuda Y, Dohi Y, Kitagawa T, Ishibashi K, Maruhashi T.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-26 – 2015-04-26
• [Presentation] Subpopulations of Regulatory T Cells Abnormalities in Pulmonary Arterial Hypertension. (2015)
  • Author(s): Sada Y, Uga S, Higashi A, Kinoshita H, Dohi Y, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-26 – 2015-04-26
• [Presentation] Who is the Operator, That is the Problem: A Multicenter Study. (2015)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Hirayama H, Hashimoto H, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-26 – 2015-04-26
• [Presentation] Poor Left Ventricular Reverse Remodeling in Patients with Systolic Heart Failure and Atrioventricular Block who Responded to Cardiac Resynchronization. (2015)
  • Author(s): Sairaku A, Yoshida Y, Maeda M, Hirayama H, Nakano Y, Hashimoto H, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-26 – 2015-04-26
• [Presentation] The Outcome after Cardiac Resynchronization Therapy for the Patients with Cardiac Sarcoidosis. (2015)
  • Author(s): Sairaku A, Yoshida Y, Maeda M, Hirayama H, Nakano Y, Hashimoto H, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-26 – 2015-04-26
• [Presentation] Relation of Inflammation and Neoangiogenesis in Epicardial Adipose Tissue to Coronary Atherosclerosis Based on Computed Tomography Analysis. (2015)
  • Author(s): Kitagawa T, Tsushima H, Yamamoto H, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-25 – 2015-04-25
• [Presentation] Usefulness of Isometric Handgrip in Detecting Coronary Artery Disease During Supine Bicycle Ergometer Stress Echocardiography. (2015)
  • Author(s): Masada K, Hidaka T, Maruhashi T, Ishibashi K, Kitagawa T, Dohi Y, Fukuda Y, Kurisu S, Yamamoto H, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-25 – 2015-04-25
• [Presentation] Accumulation of Epicardial Adipose Tissue Increases Coronary Morbidity in Non-obese Patients. (2015)
  • Author(s): Yamamoto H, Kunita E, Tsushima H , Kitagawa T, Watanabe N, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-24 – 2015-04-24
• [Presentation] Common Variant near HEY2 as a Protective Modifier of Ventricular Fibrillation in Brugada Syndrome. (2015)
  • Author(s): Nakano Y, Ochi H, Toshishige M, Ikenaga H, Oda N, Tokuyama T, Sairaku A, Watanabe Y, Kawazoe H, Matsumura H, Tomomori S, Oda N, Kishimoto S, Uchimura-Makita Y, Motoda C, Fujiwara M, Kajihara K, Itakura K, Chayama K, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-24 – 2015-04-24
• [Presentation] Resting Periodic Breathing before Cardiopulmonary Exercise Testing was Strongly Correlated with Future Cardiovascular Events in Heart Failure Patients. (2015)
  • Author(s): Kinoshita H, Dohi Y, Uga S, Higashi A, Sada Y, Tokuyama T, Maruhashi T, Kisaka T, Ishibashi K, Kitagawa T, Hidaka T, Fukuda Y, Kurisu S, Nakano Y, Yamamoto H, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-24 – 2015-04-24
• [Presentation] Difficulty to Predict Histological Cardiac Abnormalities in Brugada Syndrome Patients Using Late Potential. (2015)
  • Author(s): Watanabe Y, Nakano Y, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-24 – 2015-04-24
• [Presentation] Napkin-ring Sing is Associated with Luminal Narrowing and Plaque Volume: Evaluation in Patients with Zero Coronary Calcium Score. (2015)
  • Author(s): Tsushima H, Yamamoto H, Kitagawa T, Watanabe N, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-24 – 2015-04-24
• [Presentation] Association between the Duration of Statin Therapy and Periprocedural Myocardial Injury in Patients Undergoing Percutaneous Coronary Intervention. (2015)
  • Author(s): Shimonaga T, Kurisu S, Watanabe N, Higaki T, Ikenaga H, Iwasaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y.
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2015-04-24 – 2015-04-24
• [Book] ここが知りたい 強心薬のさじ加減 (2016)
  • Author(s): 木原康樹
  • Total Pages: 456
  • Publisher: (株)中外医学社
• [Book] 循環器疾患 最新の治療 (2016)
  • Author(s): 丸橋達也,木原康樹
  • Total Pages: 368
  • Publisher: (株)南山堂
• [Book] 高齢化社会と慢性心不全 (2016)
  • Author(s): 木原康樹
  • Total Pages: 200
  • Publisher: (株)メディカ出版
• [Book] 心不全診療Q&A 改訂2版 エキスパート105人からの回答 (2015)
  • Author(s): 日髙貴之,宇都宮裕人,木原康樹
  • Total Pages: 460
  • Publisher: (株)中外医学社
• [Book] 拡張不全の日常診療Q&A (2015)
  • Author(s): 日髙貴之,檜垣忠直,木原康樹
  • Total Pages: 230
  • Publisher: (株)中外医学社