ミトコンドリア酵素ALDH2遺伝子変異と心不全：iPS細胞誘導心筋細胞での検討

2016 Fiscal Year Research-status Report

• Project/Area Number: 15K09084
• Research Institution: Hiroshima University
• Principal Investigator: 木原 康樹 広島大学, 医歯薬保健学研究科(医), 教授 (40214853)
• Co-Investigator(Kenkyū-buntansha): 東 幸仁 広島大学, 原爆放射線医科学研究所, 教授 (40346490)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 心不全 / ミトコンドリア / 酸化ストレス / iPS細胞 / アルデヒド脱水素酵素 / 心房細動 / 飲酒

Outline of Annual Research Achievements

当初の研究概要:特発性拡張型心筋症患者(DCM)におけるALDH2遺伝子多型と薬剤効果および予後の関係: DCMと診断され新規に心不全に対する薬物治療を導入される患者を対象として1)ALDH2遺伝子多型を調査する。RAS 阻害薬の有効性と心事故発生率を前向きに調査する2) DCM患者末梢血から得たiPS誘導心筋細胞を用いて4HNE産生・アポトーシスとALDH2 遺伝子多型との関係をexvivoで検討する。
平成27‐28年度に判明したこと:心不全の増悪因子であると同時に心不全により誘発される代表的な不整脈である心房細動罹患患者についてのALDH2遺伝子多型を調査した。広大病院で心房細動カテーテルアブレーションを施行した577例(男性427例、平均年齢61±11歳)を健常人(非心房細動者1935例(男性881例、平均年齢36±15歳)と比較しrs671(ALDH2(Glu487Lys))保因割合を調査した。仮説に反して心房症例の方が対象群に比しALDH2マイナーアレルAは少なかった。その他のSNPについては有意差を認めなかった。孤立性心房細動症例(高血圧、器質的心疾患なし、年齢≦65歳)182例を抽出し、コントロール(高血圧、器質的心疾患なし、年齢≦65歳)の914例において同様の検討を行ったが同様であった。飲酒量と心房細動との関連は以前より言われているが今回の検討でもALDH2, ADH1BSNP genotypeと飲酒量との関係が示唆された。(J Biol Sci 23(1):89, 2016)平成28年度には健常男性2734名において内皮依存性血管弛緩能をFMD法により調査したところ軽微なアルコール飲酒習慣でもFMDは低下し飲酒量依存的に更なる低下を示した。(Int J Cardiol 230:523-8, 2017)現在対象のALDH2、ADH1遺伝子解析を進めている。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

既知の情報から推定したALDH2と酸化ストレス、それらの結果としての慢性循環器疾患の発症という構図が、心房細動を対象とすることで否定され、むしろそれとは逆の相関関係が得られた。単なる実験誤差やサンプリングエラーではないため、ALDH2マイナーアレルは日本人も含めアジア人で心血管系に保護的な役割を担っている可能性も想定される。飲酒との関係が明白な対象を検討することで、更にメカニズムに迫りたい。

Strategy for Future Research Activity

飲酒習慣とその結果としての内皮機能障害が測定された成人男子対象において、以下のSNPについて検索を実施する。
rs28999113:APRT(Adenine phosphoribosyltransferase), rs1801133:MTHFR(Methylenetetrahydrofolate Reductase), rs138687036:G6PD(Glucose-6-Phosphate Dehydrogenase), rs80338943:GJB2 deletion(Connexin 26), rs671:ALDH2(Aldehyde Dehydrogenase), rs1229984:ADH(Alcohol Dehydrogenase), rs429358:ApoE4(Apolipoprotein E), rs7412:ApoE2(Apolipoprotein E)

Causes of Carryover

消耗品の効率的な使用により、62,557円の余りが生じた。

Expenditure Plan for Carryover Budget

平成29年度に事務消耗品費、コピー用紙代等として使用予定である。

Research Products

• [Int'l Joint Research] Stanford University(米国)
  • Country Name: U.S.A.
  • Counterpart Institution: Stanford University
• [Journal Article] Coronary Artery Stent Evaluation with Model-based Iterative Reconstruction at Coronary CT Angiography (2017)
  • Author(s): Tatsugami Fuminari、Higaki Toru、Sakane Hiroaki、Fukumoto Wataru、Kaichi Yoko、Iida Makoto、Baba Yasutaka、Kiguchi Masao、Kihara Yasuki、Tsushima So、Awai Kazuo
  • Journal Title: Academic Radiology Volume: 24 Pages: 975～981
  • DOI: 10.1016/j.acra.2016.12.020
  • Peer Reviewed / Open Access
• [Journal Article] Aortic knob width reflects left ventricular diastolic function assessed by gated myocardial perfusion single photon emission computed tomography in patients with normal myocardial perfusion (2017)
  • Author(s): Kurisu Satoshi、Higaki Tadanao、Sumimoto Yoji、Ikenaga Hiroki、Watanabe Noriaki、Ishibashi Ken、Dohi Yoshihiro、Fukuda Yukihiro、Kihara Yasuki
  • Journal Title: Annals of Nuclear Medicine Volume: 31 Pages: 245～249
  • DOI: 10.1007/s12149-017-1150-y
  • Peer Reviewed
• [Journal Article] Usefulness of HATCH score in the prediction of new-onset atrial fibrillation for Asians (2017)
  • Author(s): Suenari K, Chao TF, Liu CJ, Kihara Y, Chen TJ, Chen SA
  • Journal Title: Medicine (Baltimore) Volume: 96 Pages: e5597
  • DOI: 10.1097/MD.0000000000005597
  • Peer Reviewed / Open Access
• [Journal Article] Mitral systolic velocity at peak exercise predicts impaired exercise capacity in patients with heart failure with preserved ejection fraction (2017)
  • Author(s): Masada K, Hidaka T, Harada Y, Kinoshita M, Itakura K, Higashi A, Utsunomiya H, Kihara Y
  • Journal Title: Echocardiography Volume: 34 Pages: 217-225
  • DOI: 10.1111/echo.13440
  • Peer Reviewed / Open Access
• [Journal Article] Increasing Risk of Osteoporotic Fracture Is Associated With Vascular Dysfunction and Abnormal Vascular Structure in Both Men and Women (2017)
  • Author(s): Kajikawa M, Oda N, Kishimoto S, Maruhashi T, Iwamoto Y, Iwamoto A, Matsui S, Aibara Y, Mohamad Yusoff FB, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Taguchi A, Higashi Y
  • Journal Title: Circ J Volume: - Pages: -
  • DOI: 10.1253/circj.CJ-16-1236
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial dysfunction and abnormal vascular structure are simultaneously present in patients with heart failure with preserved ejection fraction (2017)
  • Author(s): Kishimoto S, Kajikawa M, Maruhashi T, Iwamoto Y, Matsumoto T, Iwamoto A, Oda N, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Higashi Y
  • Journal Title: Int J Cardiol Volume: 231 Pages: 181-187
  • DOI: 10.1016/j.ijcard.2017.01.024
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial function is impaired in relation to alcohol intake even in the case of light alcohol consumption in Asian men; Flow-mediated Dilation Japan (FMD-J) Study (2017)
  • Author(s): Oda N, Kajikawa M, Maruhashi T, Iwamoto Y, Kishimoto S, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Higashi Y
  • Journal Title: Int J Cardiol Volume: 230 Pages: 523-528
  • DOI: 10.1016/j.ijcard.2016.12.065
  • Peer Reviewed / Open Access
• [Journal Article] Relation of the Bilateral Earlobe Crease to Endothelial Dysfunction (2017)
  • Author(s): (kajikawa M)Oda N, Maruhashi T, Kishimoto S, Kajikawa M, Iwamoto Y, Iwamoto A, Matsui S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Hirano H, Higashi Y
  • Journal Title: Am J Cardiol Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Decreased Frequency and Duration of Tooth Brushing Is a Risk Factor for Endothelial Dysfunction (2017)
  • Author(s): Matsui S, Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Nakashima A, Noma K, Taguchi A, Higashi Y
  • Journal Title: Int J Cardiol Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Reduction of Central Blood Pressure in Response to Oral Glucose Loading Is Blunted in Patients With Diabetes Mellitus (2016)
  • Author(s): Higaki T, Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Iwasaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Journal Title: Am J Hypertens Volume: 29 Pages: 357-364
  • DOI: 10.1093/ajh/hpv120
  • Peer Reviewed / Open Access
• [Journal Article] Influence of dual antiplatelet therapy on mean platelet volume in patients with coronary artery disease undergoing percutaneous coronary intervention (2016)
  • Author(s): Higaki T, Kurisu S, Watanabe N, Ikenaga H, Shimonaga T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Journal Title: Heart Vessels Volume: 31 Pages: 269-274
  • DOI: 10.1007/s00380-014-0599-z
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the Motion Correction Technique on Image Quality at 320-Detector Computed Tomography Coronary Angiography in Patients With Atrial Fibrillation (2016)
  • Author(s): Tatsugami F, Higaki T, Fukumoto W, Kaichi Y, Iida M, Fujioka C, Kiguchi M, Kihara Y, Awai K
  • Journal Title: J Comput Assist Tomogr Volume: - Pages: -
  • DOI: 10.1097/RCT.0000000000000414
  • Peer Reviewed / Open Access
• [Journal Article] Lower Radiation Exposure Needs Lower Heart Rate (2016)
  • Author(s): Yamamoto H, Kihara Y
  • Journal Title: Circ J Volume: 80 Pages: 1106-1107
  • DOI: 10.1253/circj.CJ-16-0281
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of a Novel Endothelin Receptor Antagonist, Macitentan, in Japanese Patients With Pulmonary Arterial Hypertension (2016)
  • Author(s): Tahara N, Dobashi H, Fukuda K, Funauchi M, Hatano M, Ikeda S, Joho S, Kihara Y, Kimura T, Kondo T, Matsushita M, Minamino T, Nakanishi N, Ozaki Y, Saji T, Sakai S, Tanabe N, Watanabe H, Yamada H, Yoshioka K, Sasayama S
  • Journal Title: Circ J Volume: 80 Pages: 1478-1483
  • DOI: 10.1253/circj.CJ-15-1305
  • Peer Reviewed / Open Access
• [Journal Article] Corkscrew collaterals in Raynaud's syndrome (2016)
  • Author(s): Fujii Y, Teragawa H, Kihara Y, Higashi Y
  • Journal Title: BMJ Case Rep Volume: - Pages: -
  • DOI: 10.1136/bcr-2016-215841
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between serum triglyceride levels and endothelial function in a large community-based study (2016)
  • Author(s): Kajikawa M, Maruhashi T, Matsumoto T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Aibara Y, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y
  • Journal Title: Atherosclerosis Volume: 249 Pages: 70-75
  • DOI: 10.1016/j.atherosclerosis.2016.03.035
  • Peer Reviewed / Open Access
• [Journal Article] Identifying Small Coronary Calcification in Non-Contrast 0.5-mm Slice Reconstruction to Diagnose Coronary Artery Disease in Patients with a Conventional Zero Coronary Artery Calcium Score (2016)
  • Author(s): Urabe Y, Yamamoto H, Kitagawa T, Utsunomiya H, Tsushima H, Tatsugami F, Awai K, Kihara Y
  • Journal Title: J Atheroscler Thromb Volume: 23 Pages: 1324-1333
  • DOI: 10.5551/jat.35808
  • Peer Reviewed / Open Access
• [Journal Article] Shedding light on the gray zone (2016)
  • Author(s): Tanaka H, Okada T, Kihara Y
  • Journal Title: J Thorac Dis Volume: 8 Pages: 1421-1424
  • DOI: 10.21037/jtd.2016.05.23
  • Peer Reviewed / Open Access
• [Journal Article] Editorial: Variants of takotsubo cardiomyopathy (2016)
  • Author(s): Kurisu S, Kihara Y
  • Journal Title: Journal of Cardiology Cases Volume: - Pages: -
  • DOI: org/10.1016/j.jccase.2016.04.001
  • Peer Reviewed / Open Access
• [Journal Article] Electrical remodeling of the atrioventricular node caused by persistent atrial fibrillation in humans (2016)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Tokuyama T, Kawazoe H, Matsumura H, Tomomori S, Amioka M, Kihara Y
  • Journal Title: J Cardiovasc Electrophysiol Volume: 27 Pages: 918-922
  • DOI: 10.1093/ehjci/jew039
  • Peer Reviewed / Open Access
• [Journal Article] Selvester QRS score and total perfusion deficit calculated by quantitative gated single-photon emission computed tomography in patients with prior anterior myocardial infarction in the coronary intervention era (2016)
  • Author(s): Kurisu S, Shimonaga T, Ikenaga H, Watanabe N, Higaki T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Journal Title: Heart Vessels Volume: - Pages: -
  • DOI: 10.1007/s00380-016-0884-0
  • Peer Reviewed / Open Access
• [Journal Article] Interaction Between Brain and Heart (2016)
  • Author(s): Kurisu S, Kihara Y
  • Journal Title: Circ J Volume: 80 Pages: 1905-1906
  • DOI: 10.1253/circj.CJ-16-0737
  • Peer Reviewed / Open Access
• [Journal Article] Non-suppressive regulatory T cell subset expansion in pulmonary arterial hypertension (2016)
  • Author(s): Sada Y, Dohi Y, Uga S, Higashi A, Kinoshita H, Kihara Y
  • Journal Title: Heart Vessels Volume: 31 Pages: 1319-26
  • DOI: 10.1007/s00380-015-0727-4
  • Peer Reviewed / Open Access
• [Journal Article] Clinical value of regression of electrocardiographic left ventricular hypertrophy after aortic valve replacement (2016)
  • Author(s): Yamabe S, Dohi Y, Higashi A, Kinoshita H, Sada Y, Hidaka T, Kurisu S, Shiode N, Kihara Y; HERO (Hiroshima Heart Study Group) Investigators
  • Journal Title: Heart Vessels Volume: 31 Pages: 1497-1503
  • DOI: 10.1007/s00380-015-0761-2
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Malondialdehyde-Modified Low-Density Lipoprotein on Tissue Characteristics in Patients With Stable Coronary Artery Disease - Integrated Backscatter-Intravascular Ultrasound Study (2016)
  • Author(s): Ikenaga H, Kurisu S, Kono S, Sumimoto Y, Watanabe N, Shimonaga T, Higaki T, Iwasaki T, Mitsuba N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Journal Title: Circ J Volume: 80 Pages: 2173-2182
  • DOI: 10.1253/circj.CJ-16-0451
  • Peer Reviewed / Open Access
• [Journal Article] Long-term effect of sitagliptin on endothelial function in type 2 diabetes: a sub-analysis of the PROLOGUE study (2016)
  • Author(s): Maruhashi T, Higashi Y, Kihara Y, Yamada H, Sata M, Ueda S, Odawara M, Terauchi Y, Dai K, Ohno J, Iida M, Sano H, Tomiyama H, Inoue T, Tanaka A, Murohara T, Node K; PROLOGUE Study
  • Journal Title: Cardiovasc Diabetol Volume: 15 Pages: 134
  • DOI: 10.1186/s12933-016-0438-x
  • Peer Reviewed / Open Access
• [Journal Article] Nitroglycerine-induced vasodilation in coronary and brachial arteries in patients with suspected coronary artery disease (2016)
  • Author(s): Maruhashi T, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Higaki T, Shimonaga T, Watanabe N, Ikenaga H, Hidaka T, Kihara Y, Chayama K, Goto C, Aibara Y, Noma K, Higashi Y
  • Journal Title: Int J Cardiol Volume: 219 Pages: 312-316
  • DOI: 10.1016/j.ijcard.2016.06.050
  • Peer Reviewed / Open Access
• [Journal Article] Second derivative of the finger photoplethysmogram and cardiovascular mortality in middle-aged and elderly Japanese women (2016)
  • Author(s): Inoue N, Kawakami H, Yamamoto H, Ito C, Fujiwara S, Sasaki H, Kihara Y
  • Journal Title: Hypertens Res Volume: - Pages: -
  • DOI: 10.1038/hr.2016.123
  • Peer Reviewed / Open Access
• [Journal Article] Impact of sleep on osteoporosis: sleep quality is associated with bone stiffness index (2016)
  • Author(s): Sasaki N, Fujiwara S, Yamashita H, Ozono R, Teramen K, Kihara Y
  • Journal Title: Sleep Med Volume: 25 Pages: 73-77
  • DOI: 10.1016/j.sleep.2016.06.029
  • Peer Reviewed / Open Access
• [Journal Article] Don't expect left ventricular reverse remodeling after cardiac resynchronization therapy in patients with systolic heart failure and atrioventricular block: A multicenter study (2016)
  • Author(s): Sairaku A, Yoshida Y, Nakano Y, Hirayama H, Maeda M, Hashimoto H, Kihara Y
  • Journal Title: Int J Cardiol Volume: 221 Pages: 597-600
  • DOI: 10.1016/j.ijcard.2016.06.338
  • Peer Reviewed / Open Access
• [Journal Article] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Noninvasive Scoring Methods (2016)
  • Author(s): Kawazoe H, Nakano Y, Ochi H, Takagi M, Hayashi Y, Uchimura Y, Tokuyama T, Watanabe Y, Matsumura H, Tomomori S, Sairaku A, Suenari K, Awazu A, Miwa Y, Soejima K, Chayama K, Kihara Y
  • Journal Title: Heart Rhythm Volume: 13 Pages: 1947-1954
  • DOI: 10.1016/j.hrthm.2016.07.009
  • Peer Reviewed / Open Access
• [Journal Article] Coronary CT angiography in patients with implanted cardiac devices: initial experience with the metal artefact reduction technique (2016)
  • Author(s): Tatsugami F, Higaki T, Sakane H, Fukumoto W, Iida M, Baba Y, Fujioka C, Kihara Y, Tsushima S, Awai K
  • Journal Title: Br J Radiol Volume: 80 Pages: -
  • DOI: 10.1259/bjr.20160493
  • Peer Reviewed / Open Access
• [Journal Article] Response to "circulating level of pigment epithelium-derived factor is associated with vascular function and structure: Methodological issues" (2016)
  • Author(s): Kajikawa M, Hida E, Kihara Y, Yamagishi SI, Higashi Y
  • Journal Title: Int J Cardiol Volume: - Pages: -
  • DOI: 10.1016/j.ijcard.2016.10.100
  • Peer Reviewed / Open Access
• [Journal Article] Vascular Function and Intima-media Thickness of a Leg Artery in Peripheral Artery Disease: A Comparison of Buerger Disease and Atherosclerotic Peripheral Artery Disease (2016)
  • Author(s): Iwamoto A, Kajikawa M, Maruhashi T, Iwamoto Y, Oda N, Kishimoto S, Matsui S, Kihara Y, Chayama K, Goto C, Noma K, Aibara Y, Nakashima A, Higashi Y
  • Journal Title: J Atheroscler Thromb Volume: 23 Pages: 1261-1269
  • DOI: 10.5551/jat.35436
  • Peer Reviewed / Open Access
• [Journal Article] Effects of left ventricular size on the accuracy of diastolic parameters derived from myocardial perfusion SPECT: comparison with tissue Doppler echocardiography (2016)
  • Author(s): Kurisu S, Sumimoto Y, Ikenaga H, Watanabe N, Ishibashi K, Dohi Y, Hidaka T, Fukuda Y, Kihara Y
  • Journal Title: Ann Nucl Med Volume: 30 Pages: 645-651
  • DOI: 10.1007/s12149-016-1111-x
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of New-Onset Atrial Fibrillation in Patients With Non-Hodgkin's Lymphoma Treated With Anthracyclines (2016)
  • Author(s): Amioka M, Sairaku A, Ochi T, Okada T, Asaoku H, Kyo T, Kihara Y
  • Journal Title: Am J Cardiol Volume: 118 Pages: 1386-1389
  • DOI: 10.1016/j.amjcard.2016.07.049
  • Peer Reviewed / Open Access
• [Journal Article] Dexmedetomidine depresses sinoatrial and atrioventricular nodal function without any change in atrial fibrillation inducibility (2016)
  • Author(s): Sairaku A, Nakano Y, Suenari K, Tokuyama T, Kawazoe H, Matsumura H, Tomomori S, Amioka M, Kihara Y
  • Journal Title: J Cardiovasc Pharmacol Volume: 68 Pages: 473-478
  • DOI: 10.1097/FJC.0000000000000434
  • Peer Reviewed / Open Access
• [Journal Article] Circulating level of pigment epithelium-derived factor is associated with vascular function and structure: A cross-sectional study (2016)
  • Author(s): Kajikawa M, Maruhashi T, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Aibara Y, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Matsui T, Yamagishi SI, Higashi Y
  • Journal Title: Int J Cardiol Volume: 225 Pages: 91-95
  • DOI: 10.1016/j.ijcard.2016.09.123
  • Peer Reviewed / Open Access
• [Journal Article] Genetic variations of aldehyde dehydrogenase 2 and alcohol dehydrogenase 1B are associated with the etiology of atrial fibrillation in Japanese (2016)
  • Author(s): Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironomobe N, Motoda C, Oda N, Chayama K, Chen CH, Gross ER, Mochly-Rosen D, Kihara Y
  • Journal Title: J Biomed Sci Volume: 23 Pages: 89
  • DOI: 10.1186/s12929-016-0304-x
  • Peer Reviewed / Open Access
• [Journal Article] Association of sleep habits with blood pressure in elderly people (2016)
  • Author(s): Sasaki N, Ozono R, Yamashita H, Ashimen H, Miyamoto Y, Iwami S, Yuzono N, Fujiwara S, Kihara Y
  • Journal Title: Clin Exp Hypertens Volume: 38 Pages: 733-737
  • DOI: 10.1080/10641963.2016.1200066
  • Peer Reviewed / Open Access
• [Journal Article] Implications of World Health Organization classification for body mass index on the correlations between common electrocardiographic indexes for left ventricular hypertrophy and left ventricular mass (2016)
  • Author(s): Kurisu S, Ikenaga H, Watanabe N, Higaki T, Shimonaga T, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Journal Title: Clin Exp Hypertens Volume: 38 Pages: 715-720
  • DOI: 10.1080/10641963.2016.1200604
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of 8-frame and 16-frame thallium-201 gated myocardial perfusion SPECT for determining left ventricular systolic and diastolic parameters (2016)
  • Author(s): Kurisu S, Sumimoto Y, Ikenaga H, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Journal Title: Heart Vessels Volume: - Pages: -
  • DOI: 10.1007/s00380-016-0935-6
  • Peer Reviewed / Open Access
• [Journal Article] Endothelial Function Assessed by Automatic Measurement of Enclosed Zone Flow-Mediated Vasodilation Using an Oscillometric Method Is an Independent Predictor of Cardiovascular Events (2016)
  • Author(s): Morimoto H, Kajikawa M, Oda N, Idei N, Hirano H, Hida E, Maruhashi T, Iwamoto Y, Kishimoto S, Matsui S, Aibara Y, Hidaka T, Kihara Y, Chayama K, Goto C, Noma K, Nakashima A, Ukawa T, Tsuji T, Higashi Y
  • Journal Title: J Am Heart Assoc Volume: - Pages: -
  • DOI: 10.1161/JAHA.116.004385
  • Peer Reviewed / Open Access
• [Presentation] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Clinical and Molecular Biological Parameters is useful for Deciding an Optimal Therapeutic Strategy (2017)
  • Author(s): Nakano Y, Kawazoe H, Ochi H, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironobe N, Motoda C, Onohara Y, Chayama K, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
  • Invited
• [Presentation] Variants of Aldehyde Dehydrogenase 2 and Alcohol Dehydrogenase Genes are Associated with Atrial Fibrillation (2017)
  • Author(s): Nakano Y, Ochi H, Onohara Y, Sairaku A, Tokuyama T, Matsumura H, Tomomori S, Amioka M, Hironobe N, Motoda C, Oda N, Chayama K, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] 心臓血管外科術後多職種リハビリテーション外来の効果の検討 (2017)
  • Author(s): 中山奨,高橋信也,中麻規子,磨野浩子,中山満誉,金井香菜,島田和美,木村浩彰,木原康樹
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Mitral Systolic Velocity at Peak Exercise Predicts Impaired Exercise Capacity in Patients with Heart Failure with Preserved Ejection Fraction (2017)
  • Author(s): Masada K, Hidaka T, Kinoshita M, Higashi A, Utsunomiya H, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Significance of Focally Increased 18F-Sodium Fluoride Activity in Identifying High-Risk Coronary Plaques in Combination with Computed Tomography Angiography (2017)
  • Author(s): Kitagawa T, Yamamoto H, Senoo A, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Sinus Node Recovery Time and ZFHX3 SNP Minor Allele were Independent Predictors of Atrial Fibrillation Recurrence after Pulmonary Vein Isolation (2017)
  • Author(s): Tomomori S, Nakano Y, Tokuyama T, Sairaku A, Matsumura H, Amioka M, Hironobe N, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Irx6 Regulates Cardiac Inflammation by Balancing RXR Signals (2017)
  • Author(s): Motoda C, Yuasa S, Kihara Y, Fukuda K
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Can NT-pro BNP predict left atrial pressure in patients with persistent atrial fibrillation: Lame duck or smart apple? (2017)
  • Author(s): Amioka M, Sairaku A, Hironobe N, Tomomori S, Matsumura H, Tokuyama T, Nakano Y, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] A common SCN5A polymorphism H558R modifies cis-allelic expression level of SCN5A by modulating DNA methylation of SCN5A promoters (2017)
  • Author(s): Matumura H, Nakano Y, Sairaku A, Tokuyama T, Tomomori S, Amioka M, Hironobe N, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Early Mitral Diastolic Inflow Velocity to Global Longitudinal Strain Ratio is an Independent Predictor of Exercise Capacity in Heart Failure (2017)
  • Author(s): Masada K, Hidaka T, Kinoshita M, Higashi A, Utsunomiya H, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Serum Inflammatory Markers and Immunoglobulin G4-Related Periaortitis as Detected by Computed Tomography (2017)
  • Author(s): Yamamoto H, Kitagawa T, Senoo A, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Systolic Mitral Annular Velocity during Exercise is a Useful Parameter for the Detection of Hear Failure with Preserved Ejection Fraction (2017)
  • Author(s): Hidaka T, Masada K, Utsunomiya H, Kinoshita H, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Contribution of Inflammatory Cytokines in Epicardial Adipose Tissue to Coronary Atherosclerosis Based on Computed Tomography Analysis (2017)
  • Author(s): Kitagawa T, Senoo A, Takahashi S, Yamamoto H, Sueda T, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Aortic knob width on chest radiography reflects left ventricular diastolic function assessed by gated SPECT in patients with normal myocardial perfusion (2017)
  • Author(s): Kurisu S, Sumimoto Y, Ikenaga H, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] The predictors of late recurrence after pulmonary vein isolation in patients with non-paroxysmal atrial fibrillation (2017)
  • Author(s): Amioka M, Nakano Y, Hironobe N, Tomomori S, Tokuyama T, Sairaku A, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Perspectives in Managing End-stage Heart-failure Patients in Japan (2017)
  • Author(s): Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
  • Invited
• [Presentation] Reduction in Mitral Valve Area after Percutaneous Edge-to-edge Repair and its Association with Pulmonary Hypertension: an intraprocedural 3DTEE study (2017)
  • Author(s): Utsunomiya H, Itabashi Y, Kobayashi S, Hidaka T, Kihara Y, Shiota T
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] Impact of Pathological Features of Epicardial Adipose Tissue on Coronary Plaque Characteristics Verified on Computed Tomography Angiography (2017)
  • Author(s): Senoo A, Kitagawa T, Yamamoto H, Takahashi S, Kubo Y, Sueda T, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-19
• [Presentation] The Prognostic Value of CPET: Association With Coronary Artery Calcium Score (2017)
  • Author(s): Hakimi M, Kisaka T, Sietsema K, Kihara Y, Wasserman K, Budoff M
  • Organizer: American College of Cardiology 2017
  • Place of Presentation: Washington DC,USA
  • Year and Date: 2017-03-17 – 2017-03-19
  • Int'l Joint Research
• [Presentation] Predictive and prognostic value of plaque morphology assessed by frequency-domain optical coherence tomography and intracoronary electrocardiogram after elective stent implantation (2017)
  • Author(s): Ikenaga H ,Kurisu S, Sumimoto Y, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-17
• [Presentation] Impact of malodialdehyde-modified low-density lipoprotein on short-and long-term clinical outcomes after elective percutaneous coronary intervention (2017)
  • Author(s): Ikenaga H, Kurisu S, Sumimoto Y, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-17
• [Presentation] Usefulness of Left atrial appendage wall velocity to predict left atrial spontaneous echo contrast in patients with severe aortic stenosis (2017)
  • Author(s): Fukuda Y, Susawa H, Sumimoto Y, Kinoshita M, Itakura K, Masada K, Watanabe N, Ikenaga H, Utsunomiya H, Ishibashi K, Dohi Y, Hidaka T, Kurisu S, Kihara Y
  • Organizer: 第81回日本循環器学会学術集会
  • Place of Presentation: 石川県
  • Year and Date: 2017-03-17 – 2017-03-17
• [Presentation] Variants Of Aldehyde Dehydrogenase 2 And Alcohol Dehydrogenase Genes Are Associated With Atrial Fibrillation (2016)
  • Author(s): Nakano Y, Ochi H, Tomomori S, Matsumura H, Tokuyama T, Sairaku A, Motoda C, Chayama K, Chen C, Mochly-Rosen D, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] A Significant Correlation Between Nitroglycerine-induced Vasodilation in Coronary and Brachial Arteries (2016)
  • Author(s): Maruhashi T, Higashi Y, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Higaki T, Shimonaga T, Watanabe N, Ikenaga H, Hidaka T, Aibara Y, Noma K, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] A common SCN5A polymorphism H558R modifies clinical phenotype of Brugada syndrome by modulating DNA methylation of SCN5A promoters (2016)
  • Author(s): Matsumura H, Nakano Y, Sairaku A, Tokuyama T, Tomomori S, Amioka M, Hironobe N, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] A common genetic variant within SCN10A modulates DNA methylation of SCN5A Promoters (2016)
  • Author(s): Hironobe N, Nakano Y, Tokuyama T, Sairaku A, Matsumura H, Tomomori S, Amioka M, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Risk Stratification of Ventricular Fibrillation in Brugada Syndrome Using Logistic Models of Noninvasive Parameters (2016)
  • Author(s): Nakano Y, Kawazoe H, Ochi H, Takagi M, Tokuyama T, Sairaku A, Matsumura H, Tomomori S, Amioka M, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] A novel approach to tailor heparin dosage during ablation of atrial fibrillation: an assessment of sensitivity to unfractionated heparin (2016)
  • Author(s): Sairaku A, Nakano Y, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Predictive Value of Plaque Morphology Assessed by Frequency-Domain Optical Coherence Tomography for Periprocedural Myocardial Injury after Elective Stent Implantation -the Intracoronary Electrocardiogram Study- (2016)
  • Author(s): Ikenaga H, Kurisu S, Sumimoto Y, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Impact of Malondialdehyde-Modified Low-density Lipoprotein on Tissue Characteristics in Patients with Stable Coronary Artery Disease -Integrated-Backscatter Intravascular Ultrasound Study- (2016)
  • Author(s): Ikenaga H, Kurisu S, Sumimoto Y, Watanabe N, Ishibashi K, Dohi Y, Fukuda Y, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] 18F-Sodium Fluoride Positron Emission Tomography for Molecular Imaging of Coronary Atherosclerosis Based on Computed Tomography Analysis (2016)
  • Author(s): Kitagawa T, Yamamoto H, Toshimitsu S, Sasaki K, Senoo A, Hirokawa Y, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] The Impaired Response of The Arteriovenous Oxygen Content Difference to Exercise Contributes to The Progression of Heart Failure with Preserved Ejection Fraction (2016)
  • Author(s): Hidaka T, Masada, K, Kinoshita M, Itakura K, Utsunomiya H, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Light to moderate alcohol consumption does not alter endothelial function (2016)
  • Author(s): Oda N, Higashi Y, Maruhashi T, Kajikawa M, Kishimoto S, Matsui S, Iwamoto Y, Hidaka T, Nakashima A, Noma K, Tomiyama H, Takase B, Yamashina A, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Common variant in PITX2 contributes to the pathogenesis of paroxysmal atrial fibrillation by impairing sinus node function and progression of atrial remodeling (2016)
  • Author(s): Tomomori S, Nakano Y, Tokuyama T, Sairaku A, Matsumura H, Amioka M, Hironobe N, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Sinus node recovery time and minor allele of ZFHX3 SNP were independent predictors of atrial fibrillation recurrence after pulmonary vein isolation (2016)
  • Author(s): Tomomori S, Nakano Y, Tokuyama T, Sairaku A, Matsumura H, Amioka M, Hironobe N, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Extracorporeal Cardiopulmonary Resuscitation for Unwitnessed Cardiac Arrest (2016)
  • Author(s): Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Nagai M, Kihara Y
  • Organizer: American Heart Association 2016
  • Place of Presentation: New Orleans,USA
  • Year and Date: 2016-11-12 – 2016-11-16
  • Int'l Joint Research
• [Presentation] Vascular Smooth Muscle Function in Coronary and Brachial artery in Patients with Suspected Coroanry Artery Disease (2016)
  • Author(s): Maruhashi T, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Kishimoto S, Matsui S, Noma K, Kihara Y, Higashi Y
  • Organizer: Pulse of Asia 2016 Seoul
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2016-09-24 – 2016-09-26
  • Int'l Joint Research
• [Presentation] Impact of Triglycerides as Residual Risk for Cardiovascular Events on Endothelial Function: FMD-Japan Registry (2016)
  • Author(s): Kajikawa M, Maruhashi T, Oda N, Kishimoto S, Matsui S, Hidaka T, Kihara Y, Noma K, Nakashima A, Tomiyama H, Takase B, Yamashina A, Higashi Y
  • Organizer: Pulse of Asia 2016 Seoul
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2016-09-24 – 2016-09-26
  • Int'l Joint Research
• [Presentation] Vascular Function and Rho-associated Kinase Activity in Patients with Idiopathic hyperaldosteronism (2016)
  • Author(s): Kishimoto S, Higashi Y,Maruhashi T, Kajikawa M, Nakashima A, Iwamoto Y, Iwamoto A, Oda N, Matsui S, Hidaka T, Aibara Y, Noma K, Kihara Y
  • Organizer: Pulse of Asia 2016 Seoul
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2016-09-24 – 2016-09-26
  • Int'l Joint Research
• [Presentation] Endothelial Function Is Impaired in Subjects with Decreased Frequency and Duration of Tooth Brushing (2016)
  • Author(s): Matsui S, Higashi Y, Kajikawa M, Maruhashi T, Iwamoto A, Oda N, Kishimoto S, Hidaka T, Aibara Y, Nakashima A, Noma K, Kihara Y
  • Organizer: Pulse of Asia 2016 Seoul
  • Place of Presentation: Seoul,Korea
  • Year and Date: 2016-09-24 – 2016-09-26
  • Int'l Joint Research
• [Presentation] Newly Developed Atrial Fibrillation Is an Unfavorable Sign of Anthracycline-induced Cardiomyopathy (2016)
  • Author(s): Amioka M, Sairaku A, Ochi T, Okada T, Asaoku H, Nakano Y, Kihara Y
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma,Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Right ventricular function derived from echocardiography is strongly related with a right heart-pulmonary system rather than with right ventricular contractility (2016)
  • Author(s): Dohi Y, Higashi A, Ishibashi K, Hidaka T, Kurisu S, Yamamoto H, Kihara Y
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma,Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Sleep quality but not sleep quantity is associated with the prevalence of hypertension in middle-aged men:the hiroshima sleep and healthcare study (2016)
  • Author(s): Sasaki N, Ozono R, Teramen K, Yamashita H, Fujiwara S, Kihara Y
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma,Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Long-term outcomes of patients treated with unplanned venoarterial extracorporeal membrane oxygenation (2016)
  • Author(s): Kagawa E, Dote K, Kato M, Sasaki S, Oda N, Nakano Y, Nagai M, Yamane A, Kubo Y, Higashihara T, Miyauchi S, Kihara Y
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma,Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] Predictors of the pulmonary vein isolation responders in terms of left atrial deformation and hemodynamics in patients with atrial fibrillation (2016)
  • Author(s): Suenari K, Tomomori S, Matsumura H, Kawazoe H, Tokuyama T, Sairaku A, Nakano Y, Kihara Y
  • Organizer: European Society of Cardiology 2016
  • Place of Presentation: Roma,Italy
  • Year and Date: 2016-08-27 – 2016-08-31
  • Int'l Joint Research
• [Presentation] ALDH2 variations and atrial fibrillation in Japanese (2016)
  • Author(s): Kihara Y, Nkano Y, Chen CH, Gross ER, Mochly-Rosen D
  • Organizer: The 2nd Stanford-Taiwan ALDH2 Deficiency Research (STAR) Consortium Symposium, July 30, 2016
  • Place of Presentation: Taipei Medical University, Taipei, ROC
  • Year and Date: 2016-07-30 – 2016-07-30
  • Int'l Joint Research / Invited
• [Book] エビデンスに基づく 循環器看護ケア関連図 (2017)
  • Author(s): (執筆協力)石橋堅,宇都宮裕人,北川知郎,木原康樹,栗栖智,土肥由裕,德山丈仁,中野由紀子,日髙貴之,福田幸弘,丸橋達也
  • Total Pages: 376
  • Publisher: 中央法規出版(株)
• [Book] 心不全ケアチーム構築マニュアル (2016)
  • Author(s): 木原康樹
  • Total Pages: 200
  • Publisher: (株)メディカ出版
• [Book] 知っておきたい心臓病の救急 (2016)
  • Author(s): 木原康樹,日髙貴之,土肥由裕,福田幸弘,栗栖智,中野由紀子
  • Total Pages: 25
  • Publisher: 広島県医師会
• [Book] 高齢心不全患者の治療に関するステートメント (2016)
  • Author(s): 安達仁,安斉俊久,猪又孝元,木原康樹,佐藤幸人,清野精彦,筒井裕之,原田和昌,福本義弘,増山理,百村伸一,弓野大,横山広行,吉川勉
  • Total Pages: 55
  • Publisher: (一社)日本心不全学会