Mitochondrial ALDH2 Genotype and Heart Failure

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09084
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Hiroshima University
• Principal Investigator: Kihara Yasuki 広島大学, 医歯薬保健学研究科(医), 教授 (40214853)
• Co-Investigator(Kenkyū-buntansha): 東 幸仁 広島大学, 原爆放射線医科学研究所, 教授 (40346490)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ミトコンドリア / アルデヒド脱水酸化酵素 / 心不全 / 心房細動

Outline of Final Research Achievements

Mitochondrial Aldehyde dehydrogenase 2 (ALDH2) is a crucial controller of subcellular oxidative stress and the subsequent cellular damages. Its SNP causes substantial depression of the enzymatic activity, and it could be a potent background of several cardiovascular diseases such as arrhythmia and heart failure. We tested hypothesis that, in Japanese, paroxysmal and persistent atrial fibrillation (Afib, an indicator of the second stage cardiac damage) may precipitate among the ALDH2 hetero-/homo-genetic population. By comparing control (non-Afib) group, however, there were no apparent precipitation of ALDH2 heterogeneity. In contrast, Afib group showed rather less ALDH2 heterogeneity. Effects of longstanding alcohol consumption may cover the hypothetic frames.

Free Research Field

循環器内科学