2017 Fiscal Year Final Research Report
To clarify pathogenesis of hypertrophic obstructive cardiomyopathy
| Project/Area Number |
15K09097
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Hamamatsu University School of Medicine (2017)
Keio University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 肥大型心筋症 / 心不全 |
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| Outline of Final Research Achievements |
One hundred fourteen HCM patients underwent biomarker analyses.They divided into 2 groups: 52 reverse curve type and 62 other types based on septal morphologies. Serum BNP, hscTnT, and ET-1 levels were significantly higher in reverse curve group. Serum hsCRP, PTX3 and other circulating biomarkers of collagen synthesis levels had no significant differences between two groups. Reverse curve HCM group had higher percentage of late gadolinium enhancement (LGE) positive in cardiac MRI. Conclusions: Reverse curve HCM patients had higher BNP, hscTnT, and ET-1 levels and higher percentage of LGE positive, suggesting progressive myocardial damage and fibrosis.
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| Free Research Field |
肥大型心筋症
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