2017 Fiscal Year Final Research Report
Development of novel cell transplantation method using cardiomyocytes derived from human iPS cells with microvessel structure
| Project/Area Number |
15K09098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJITA Jun 慶應義塾大学, 医学部, 特任准教授 (10306706)
FUKUDA Keiichi 慶應義塾大学, 医学部, 教授 (20199227)
FUKUDA Junji 横浜国立大学, 大学院工学研究院, 准教授 (80431675)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 心筋再生医療 / iPS由来心筋細胞 |
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| Outline of Final Research Achievements |
By using a special incubator with an oxygen permeable poly-dimethylsiloxane (PDMS) membrane as the bottom surface, it was possible to product myocardial spheroids. These cardiomyocytes tended to have a high myosin light chain (MLY 2) which is a maturation marker. On the other hand, in the conventional incubator that does not permeate oxygen, the tendency of target gene expression of Hypoxia-Inducible Factor (HIF) was high.
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| Free Research Field |
心筋再生
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