2017 Fiscal Year Final Research Report
Phosphorylase phosphorylation in the heart failure development
| Project/Area Number |
15K09134
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
Konno Tetsuo 金沢大学, 医学系, 助教 (50377389)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
林 研至 金沢大学, 附属病院, 助教 (00422642)
小田 彰史 名城大学, 薬学部, 教授 (50433511)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
WAKIMOTO Hiroko ハーバード大学
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 心不全 / リン酸化 |
|---|
| Outline of Final Research Achievements |
We aimed to investigate the role of phosphorylase in the development of heart failure. In vitro forward assay showed that WT-phosphorylase activity was significantly decreased compared with ThrXAla phosphorylase and ThrXAsp phosphorylase. This association was also observed in the reverse gel assay.
|
| Free Research Field |
循環器内科
|
