2017 Fiscal Year Final Research Report
Blockade of TRPC6/3 is a Novel Therapeutic Approach Against Pulmonary Arterial Hypertension
| Project/Area Number |
15K09137
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cardiovascular medicine
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
桑原 宏一郎 信州大学, 学術研究院医学系, 教授 (30402887)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
Mori Yasuo 京都大学, 大学院工学研究科, 教授 (80212265)
Nishida Motohiro 大学共同利用機関法人自然科学研究機構, 心臓シグナル研究部門, 教授 (90342641)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 肺動脈性肺高血圧症 / 心不全 |
|---|
| Outline of Final Research Achievements |
In this study, we examined the role of transient receptor potential subfamily C (TRPC) 6/3 in pulmonary artreial hypertension. In mice and rat model of pulmonary hypertension, blockade of TRPC6/3 significantly inhibited elevation of pulmonary arterial pressure and right ventricular hypertrophy. These results suggest that Blockade of TRPC6/3 could be an novel therapeutic strategy for preventing pulmonary arterial hypertension.
|
| Free Research Field |
肺高血圧症
|
