Study of biomarkers in respiratory disease based on the expression analysis of miRNAs in blood and epithelial lining fluid.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09179
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kagoshima University
• Principal Investigator: SAMUKAWA Takuya 鹿児島大学, 医歯学域附属病院, 講師 (10363623)
• Co-Investigator(Kenkyū-buntansha): 井上 博雅 鹿児島大学, 医歯学域医学系, 教授 (30264039)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 呼吸器疾患 / バイオマーカー / 気道上皮被覆液 / miRNA

Outline of Final Research Achievements

1.Serum B cell-activating factor (BAFF) may be a useful marker for distinguish connective tissue disease associated interstitial lung disease from chronic fibrosing interstitial pneumonia. 2. miRNA-218 on lung squamous cell carcinoma directly regulates oncogenic TDP52 and appears to function as a tumor suppresser through targeting of TDP52. 3.Evaluation of napsin A levels in epithelial lining fluid may be useful for distinguishing primary lung adenocarcinoma.

Free Research Field

呼吸器内科学