2017 Fiscal Year Final Research Report
PI3K-PTEN imbalance is a potential new therapeutic target in COPD
| Project/Area Number |
15K09185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
Asai Kazuhisa 大阪市立大学, 大学院医学研究科, 講師 (10382053)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 慢性閉塞性肺疾患 / PI3K / PTEN |
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| Outline of Final Research Achievements |
The PI3K (Phosphoinositide 3-kinase) -Akt signaling pathway is involved in angiogenesis,apoptosis,cell proliferation,production of inflammatory cytokines. And there is antagonistic mechanism by PTEN (Phosphatase and Tensin Homolog Deleted from Chromosome 10).
Airway epithelial cells were collected from 22 healthy non-smokers,31 healthy smokers, and 49 COPD patients.The expression of PI3K, PTEN in airway epithelial cells and its involvement in COPD pathogenesis were examined. In COPD patients, PTEN expression was significantly decreased, showing a significant inverse correlation with smoking history and significant correlation with pulmonary function testing.This suggested that PTEN was involved in COPD pathogenesis.
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| Free Research Field |
閉塞性肺疾患
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