2017 Fiscal Year Final Research Report
Non-invasive pathological imaging of interstitial pneumonia using probe type confocal laser endomicroscopy
| Project/Area Number |
15K09198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
磯谷 澄都 藤田保健衛生大学, 医学部, 講師 (10351032)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 間質性肺炎 / 共焦点レーザー顕微鏡 / 内視鏡診断 |
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| Outline of Final Research Achievements |
We investigated probe type confocal laser microendoscopy images of diffuse lung diseases including UIP and NSIP. In UIP, auto-fluorescence of peripheral lung was significantly reduced than NSIP. Fragmentation of alveolar fluorescence was more observed in UIP than NSIP. In contrast, regular compression of alveolar wall was more observed in NSIP. pCLE imaging study of surgical biopsy specimens revealed that irregular alveolar wall changes, alveolar remodeling, and irregular alveolar compression are specific findings for UIP.
In cases with pulmonary alveolar proteinosis, we could confirm disease specific findings (giant alveolar cells with strong auto- fluorescence, amorphous fluid with weak fluorescence, and thin alveolar walls) even in early stage of the disease.
Theses findings suggest pCLE imaging could be a promising and non-invasive diagnostic tool for diffuse lung diseases.
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| Free Research Field |
呼吸器内科学
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