2017 Fiscal Year Final Research Report
Elucidation of the role of nitric oxide in the pathogensis and exacebation of chronic obstructive pulmonary disease and bronchial asthma using nitric oxide synthase deficient mice
| Project/Area Number |
15K09236
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
迎 寛 産業医科大学, 医学部, 非常勤医師 (80253821)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 一酸化窒素 / 一酸化窒素合成酵素 / 気管支喘息 / 慢性閉塞性疾患 / マクロファージ |
|---|
| Outline of Final Research Achievements |
We studied using nitric oxide synthase (NOS) completely deficient mice.
First, bronchial asthma mouse model was prepared using ovalbumin. As a result, eosinophilic inflammation, bronchial wall thickening, mucin production decreased in NOS completely deficient mice, and Th2 cytokines such as IL-4, IL-5 and IL-13 in the lung tissue decreased. Next, chronic obstructive pulmonary disease mouse model was prepared using pig pancreatic elastase. As a result, a significant increase of alveolar bulkhead distance and an increase of inflammatory cells were observed in NOS completely deficient mice. Thus, we suggest that NO is deeply involved in the pathology of bronchial asthma and chronic obstructive pulmonary disease.
|
| Free Research Field |
呼吸器内科学、アレルギー、間質性肺炎
|
