2017 Fiscal Year Final Research Report
Prediction of caardiovascular disease by dyslipidemia and chronic kidney disease in a general Japanese population: The Hisayama study
| Project/Area Number |
15K09267
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
二宮 利治 九州大学, 大学病院, 助教 (30571765)
清原 裕 九州大学, 医学研究院, 教授 (80161602)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 慢性腎臓病 / 脂質異常症 / 心血管病 / 追跡研究 |
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| Outline of Final Research Achievements |
The Hisayama Study is a population-based cohort study of CVD, which was established in 1961 in the town of Hisayama. A total of 2,630 community-dwelling Japanese individuals (1,107 men and 1,523 women) aged >40 years were prospectively followed up for an average of 19 years, and the association between serum non-HDL-C levels and the incidence of type-specific CVD was estimated by using a Cox proportional hazards model. At baseline, 357 subjects had CKD. During the follow-up, 186 coronary heart disease (CHD) and 277 stroke events occurred. In the CKD group, the risk of CHD was significantly higher in non-HDL-C levels of 150-189 mg/dL (hazard ratio [HR], 2.23) and in >190 mg/dL (HR, 3.20) compared to <150 mg/dL, while in the non-CKD group, the risk of CHD was significantly higher only in >190 mg/dL (HR, 2.12). Our findings suggest that the association between higher serum non-HDL-C levels and CHD was greater in individuals with CKD than those without CKD.
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| Free Research Field |
疫学
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