2017 Fiscal Year Final Research Report
The role of MRP8 as a therapeutic target in chronic kidney disease
| Project/Area Number |
15K09268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 慢性炎症 / MRP8 / 半月体形成性腎炎 / マクロファージ |
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| Outline of Final Research Achievements |
Chronic kidney disease (CKD) is one of the most prevalent diseases and leading to the necessity of renal replacement therapy, whose novel therapeutic stratedy is eagerly awaited. We have previously reported the role of chronic inflammation in CKD as well as diabetic nephropathy. In this study, we investigated the role of MRP8, one of the inflammatory endogenous ligands, in the crescentic glomerulonephritis. Our results suggested that ablation of MRP8 in myeloid cells ameliorated crescentic glomerulonephritis through affecting macrophage polarity.MRP8 could become as a theraputic target in glomerulonephritis.
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| Free Research Field |
腎臓内科学
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