2017 Fiscal Year Final Research Report
Regulation of caveolin-3 on pathomechanisms leading to muscular dystrophies
| Project/Area Number |
15K09330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大澤 裕 川崎医科大学, 医学部, 講師 (80246511)
西松 伸一郎 川崎医科大学, 医学部, 准教授 (20222185)
藤野 雅広 川崎医療福祉大学, 医療技術学部, 講師 (50633856)
村上 龍文 川崎医科大学, 医学部, 准教授 (30330591)
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| Co-Investigator(Renkei-kenkyūsha) |
FUKADA So-ichiro 大阪大学, 薬学研究科, 准教授 (20432445)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | シグナル伝達 / 遺伝子 / 福祉・医療 / ナノ材料 / マイクロアレイ |
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| Outline of Final Research Achievements |
Caveolin-3, which forms the inner membrane of the muscle cell membrane caveolae, is a scaffold protein of various signal transductions. In Duchenne muscular dystrophy (DMD), caveolin-3 is highly expressed, but its role in its pathology remains unknown. In this study, we developed caveolin-3 highly expressing DMD model mice and investigated whether caveolin-3 inhibits or promotes the dystrophic changes in DMD model mice. Both dystrophic change and myofiber atrophy were improved in caveolin-3 highly expressing DMD model mice, compared to DMD model mice. These findings indicate that caveolin-3 shows an inhibitory effects on the pathogenesis leading to DMD. We are currently elucidating the molecular mechanisms through caveolin-3.
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| Free Research Field |
神経内科学
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