Molecular mechanisms of anti-inflammatory and anti- diabetic effects in the activation of heat shock response

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09394
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kumamoto University
• Principal Investigator: Kondo Tatsuya 熊本大学, 医学部附属病院, 講師 (70398204)
• Co-Investigator(Kenkyū-buntansha): 荒木 栄一 熊本大学, 大学院生命科学研究部(医), 教授 (10253733)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖尿病 / 抗炎症 / ミトコンドリア

Outline of Final Research Achievements

Activation of heat shock response exerts anti-inflammatory and anti-diabetic effects in mouse models of type 2 diabetes as well as in human type 2 diabetes.
In this study, we have investigated the mechanisms of heat shock response activation in vitro, in vivo and in vivo human. As a result, we have identified the mRNA reductions of inflammatory cytokines in liver, muscle and fat. We also observed the induction of mitochondria associated genes, that may explain the increase in energy expenditure. In human monocytes, pro-inflammatory prone phenotype was attenuated by the activation of heat shock response.

Free Research Field

糖尿病