2017 Fiscal Year Final Research Report
Serum markers for early diagnosis of fulminant type 1 diabetes
| Project/Area Number |
15K09402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐野 寛行 大阪医科大学, 医学部, 助教 (20556435)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 劇症1型糖尿病 / 抗ＣＤ300e抗体 |
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| Outline of Final Research Achievements |
The present study clarified a novel biomarker anti-CD300e antibody to diagnose fulminant type 1 diabetes (FT1D). Seromic analysis revealed 9 antibodies which showed high signals in sera from patients with FT1D in acute phase. Among them, the titre of anti-CD300e antibody was significantly higher in FT1D patients in acute phase than that in autoimmune type 1 diabetes (T1AD), type 2 diabetes (T2D), autoimmune thyroid disease (AITD) patients and healthy controls (HC) by ELISA.
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| Free Research Field |
糖尿病 免疫学
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