Hepatic amino acid-mTOR pathway plays an important role in the development of metabolic syndrome

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09407
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: Uno Kenji 東北大学, 大学病院, 助教 (50596632)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: メタボリックシンドローム / mTOR / 肥満 / 臓器間神経ネットワーク / 糖代謝

Outline of Final Research Achievements

In mammals, the interorgan neuronal network, centered upon the brain, is considered to play an important role in maintaining metabolic homeostasis in the whole-body levels. However, it has been demonstrated that nutrient overloads due to food energy excess deteriorates this neuronal system and then contributes to the development of obesity and metabolic syndrome.
In this study, we focus on both hepatic amino acid (AA) metabolism and mTOR pathway, the downstream target of AA signaling. Modulation of hepatic AA-mTOR pathway through adenoviral gene delivery system has identified the internutrient coordination among AA and lipid metabolism, which is mediated by interorgan neuronal system. In the future, the additional works are needed to clarify new neuronal networks and molecular targets for the regulation of these networks.

Free Research Field

医歯薬学