Understanding of the pathogenesis of thyroid disorder by studying the effect of colloidal Tg on gene regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09444
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Teikyo University
• Principal Investigator: Suzuki Koichi 帝京大学, 医療技術学部, 教授 (20206478)
• Research Collaborator: KAWASHIMA Akira ; ISHIDO Yuko ; LUO Yuqian ; YOSHIHARA Aya ; ODA Kenzaburo ; USUKURA Kensei
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 甲状腺 / サイログロブリン / 甲状腺ホルモン / 遺伝子発現

Outline of Final Research Achievements

We have uncovered that high concentration of thyroglobulin accumulated in the follicular lumen of the thyroid has two distinct activity: one is to suppress gene expressions necessary for biosynthesis of thyroid hormone and iodine transport and the other is rather to enhance colloid resorption, hydrolysis, transport, and secretion. This evidence indicates that follicular thyroglobulin is the intrinsic autoregulator of thyroid hormone biosynthesis, its storage and secretion by negative-feedback mechanisms. It is speculated that gain-of-function of this mechanism will lead to hypothyroidisms and loss-of-function will induce hyperthyroidisms.

Free Research Field

甲状腺内分泌学、分子細胞生物学、病理病態学