2017 Fiscal Year Final Research Report
Role of Prdm16 in hematopoiesis via mitochondrial metabolic pathway
| Project/Area Number |
15K09455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
|
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| Research Institution | Kyushu University |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 白血病幹細胞 |
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| Outline of Final Research Achievements |
We revealed that mitochondrial metabolic pathway plays an important role in the maintenance of hematopoietic stem cells. Leukemia stem cells produce glutathione-SH to compete with reactive oxygen species that can be harmful to stem cells. That can be provided via increased expression of amino acid transporters. These findings can lead to establish the targeted therapy of leukemia without any severe adverse effects.
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| Free Research Field |
血液内科学
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