Development of HTLV-1 carrier model mice aming for preventing ATL development

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09462
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Hamaguchi Isao 国立感染症研究所, 血液・安全性研究部, 部長 (90348780)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: HTLV-1 / ヒト化マウス / キャリア / モデルマウス

Outline of Final Research Achievements

We developed humanized mice by using NOJ (NOD/SCID/JAK3 KO) mice. Human hematopoietic stem cells were transplanted into neonatal liver of NOJ mice, HTLV-1 infected cells are administrated through the humanized mice oral. The mice were infected by HTLV-1, and we could analyze the infectious mechanism of HTLV-1 for the long periods.
Furthermore, we have developed new immunodeficient mice with HLA-A*02:01 gene (NOG-HLA-A2 Tg). Hematopoietic stem cells that contained HLA-A*02:01 were transplanted into the humanized mice. These mice would be appropriate for extrapolation to human HTLV-1 carrier.

Free Research Field

血液学、ウイルス学