Development of a novel therapeutic strategy targeting CD38+CD43+ B cell for SLE based on gene expression profile

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09515
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Collagenous pathology/Allergology
• Research Institution: Tohoku University
• Principal Investigator: FUJII HIROSHI 東北大学, 医学系研究科, 准教授 (30531321)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 全身性エリテマトーデス / インターフェロンα / B細胞

Outline of Final Research Achievements

We tried to develop the novel therapeutic strategy for SLE by analysis of gene expression profiling of plasmablast, naive B cell, memory B cell from healthy donors and SLE patients. Whereas IFN inducible genes were significantly elevated in each B cell subset of SLE patients, cell cycle related genes were increased in SLE plasmablast. And we also showed that priming of B cell with IFNα stimulation caused to lower the threshold for B cell stimulation.

Free Research Field

膠原病