2017 Fiscal Year Final Research Report
Investigation of the role of CD226+CD8+T cells in the pathogenesis of systemic sclerosis and an application to therapy
| Project/Area Number |
15K09527
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | CD226 / 全身性強皮症 / サイトカイン / 細胞傷害活性 / CD8陽性T細胞 / IL-13 |
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| Outline of Final Research Achievements |
CD226highCD8+ T cells were increased in SSc patients compared with healthy controls and were appreciably associated with the severity of skin sclerosis and interstitial lung disease. Further, CD226highCD8+ T cells from SSc patients showed upregulated cytokine production including IL-13 and positive correlation with the cytotoxic capacity of CD8+ T cells against HUVECs. Finally, the neutralization of CD226 in CD8+ T cells impaired co-stimulation, cytokine productions, and cytolysis against HUVECs. These findings indicate that upregulated CD226 expression on CD8+ T cells reflects disease severity and are involved in SSc pathogenesis via the production of various cytokines including profibrotic IL-13 and endothelial cell injury, and that CD226 may be a useful target in the treatment of SSc.
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| Free Research Field |
医歯薬学
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