2017 Fiscal Year Final Research Report

Genetic factors of interstitial lung disease associated with polymyositis and dermatomyositis.

Research Project

Project/Area Number	15K09543
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Collagenous pathology/Allergology
Research Institution	Tokyo National Hospital (Clinical research) (2017) Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital (2015-2016)
Principal Investigator	Tohma Shigeto 独立行政法人国立病院機構東京病院(臨床研究部), 臨床研究部, 院長 (50207528)
Co-Investigator(Kenkyū-buntansha)	古川宏筑波大学, 医学医療系, 准教授 (00372293)
Project Period (FY)	2015-04-01 – 2018-03-31
Keywords	病因・病態 / 多発性筋炎 / 皮膚筋炎
Outline of Final Research Achievements	Polymyositis and dermatomyositis (PM/DM) are autoimmune diseases and are frequently complicated with interstitial lung disease. PM/DM associated interstitial lung disease (PM/DM-ILD) influenced on the prognosis of the patients. Genetic factors of rheumatoid arthritis associated interstitial lung disease have been analyzed and these genetic factors are investigated in this study. HLA-DRB108:03 and DPB105:01 were associated with the susceptibility of PM/DM and DPB1*02:01 was protectively associated with PM/DM.
Free Research Field	医歯薬学