2017 Fiscal Year Final Research Report
Analysis of the Intestinal Microbiota in Liver Transplantation.
| Project/Area Number |
15K09567
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
Miki Nagao 京都大学, 医学研究科, 准教授 (80523993)
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| Co-Investigator(Kenkyū-buntansha) |
一山 智 京都大学, 医学研究科, 教授 (30223118)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 腸内細菌叢 / 肝移植 |
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| Outline of Final Research Achievements |
Three hundred twenty fecal specimens from liver transplant recipients were analyzed. Dynamic changes were observed in the microbial composition of LT recipients during the perioperative period. Over the course of LT, the mean diversity index decreased during the first 3 weeks after LT and gradually increased during our observation period. At the family level, Bacteroides, Enterobacteriaceae, Streptococcaceae, and Bifidobacteriaceae were increased whereas Enterococcaceae, Lactobacillaceae, Clostridiaceae, Ruminococcaceae, and Peptostreptococcaceae were decreased in ACR patients.
The microbiota of LT patients was associated with the severity of liver diseases and the presence of ACR and BSI. These results lay the groundwork for more comprehensive investigations of microbiota characteristics to identify diagnostic markers for transplant health and to guide intervention strategies to improve transplant outcomes
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| Free Research Field |
感染症
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