The role of the heterotrimeric G protein, Galpha12/13 in differentiation and proliferation of smooth muscle cells.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nippon Medical School (2017); The University of Tokyo (2015-2016)
• Principal Investigator: Suzuki Nobuchika 日本医科大学, 大学院医学研究科, 研究生 (90247007)
• Co-Investigator(Kenkyū-buntansha): 川村 猛 東京大学, アイソトープ総合センター, 准教授 (70306835) ; 小笹 徹 東京大学, 先端科学技術研究センター, 特任教授 (70202059)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 平滑筋分化 / 三量体G蛋白 / リン酸化

Outline of Final Research Achievements

Losing a balance between differentiation and proliferation of smooth muscle cells causes the hereditary aortic aneurysms. Our study indicates that a heterotrimeric G protein, Galpha12 activates the pathway divergent from Galpha13.Phosphorylation of Galpha12 by TGFbeta stimulation may sustain the activation of the pathway.

Free Research Field

生化学