Analysis of Langerhans cells inhibiting CD8 T cells in cutaneous interface dermatitis

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09757
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: University of Tsukuba
• Principal Investigator: Okiyama Naoko 筑波大学, 医学医療系, 講師 (10581308)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ランゲルハンス細胞 / 自己免疫 / 苔癬反応 / 皮膚炎 / CD8 T細胞

Outline of Final Research Achievements

Langerhans cells spontaneously exist in the epidermis, which is the target of autoaggressive CD8 T cells in a murine model of interface dermatitis. Depletion of Langerhans cells induced severe dermatitis accompanied by increased number of infiltrating CD8 T cells in this model. Apoptosis of specific antigen-stimulated CD8 T cells were induced and their proliferations were inhibited when co-cultured with Langerhans cells in vitro. In conclusion, Langerhans cells regulate autoimmune interface dermatitis via inhibitory effects on autoaggressive CD8 T cells.

Free Research Field

皮膚科