2017 Fiscal Year Final Research Report
A role of FcgRIIB in systemic sclerosis
| Project/Area Number |
15K09762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 全身性強皮症 / FcγRIIB / B細胞 |
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| Outline of Final Research Achievements |
We evaluated the expression of FcγRIIB on B cell subsets in systemic sclerosis (SSc). The expressions of FcγRIIB on SSc naïve B cells and double negative (DN) memory B cells were significantly elevated than that on B cells of healthy subjects. Patients with the elavated expression of FcγRIIB on DN memory B cells more frequently had interstitial lung disease than those with normal levels. In bleomycin-induced fibrosis model, fibrosis was singnificanlty worsened in FcγRIIB-deficient mice compared to wild-type mice. Our results suggest that SSc B cells exhibit compensatory increases in the expression of FcγRIIB in order to suppress the abnormal activation of B cells, and the expression of FcγRIIB may be an indicator of the clinical severity of SSc.
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| Free Research Field |
Dermatology
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