Analysis of molecular pathophysiology of gender identity disorder using microarray method

2018 Fiscal Year Final Research Report

• Project/Area Number: 15K09806
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Okayama University
• Principal Investigator: Okahisa Yuko 岡山大学, 大学病院, 助教 (90583097)
• Project Period (FY): 2015-04-01 – 2019-03-31
• Keywords: 性同一性障害

Outline of Final Research Achievements

The purpose of this study is to reveal the molecular pathophysiology of gender identity disorder. We conducted whole-genome analysis of 206 female-to-male trans-sexual individuals and 1557 control subjects using Japonica array but failed to identify pathogenesis of gender identity disorder. We intend to perform further research using larger samples.

Free Research Field

分子精神医学

Academic Significance and Societal Importance of the Research Achievements

病態の手掛かりがない性同一性障害について全ゲノム解析を行ったことは、病態解明に向けた有意義な取り組みであったと考える。今回の解析では病態の解明につながる結果は得られなかったが、この研究を手掛かりにより多くのサンプルでの全ゲノム解析やメタボローム解析を行い、病態解明につなげたい。