A neuroimaging study exploring the biological differences between Hoarding Disorder , Obsessive-Compulsive Disorder and Anxiety Disorder

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Nakao Tomohiro 九州大学, 大学病院, 講師 (50423554)
• Co-Investigator(Kenkyū-buntansha): 村山 桂太郎 九州大学, 大学病院, 助教 (20645981) ; 樋渡 昭雄 九州大学, 大学病院, 助教 (30444855) ; 實松 寛晋 九州大学, 医学研究院, 共同研究員 (30588116)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ためこみ症 / Hoarding Disorder / OCD / prefrontal cortex / VBM / MRI

Outline of Final Research Achievements

Seventeen patients who met the DSM-5 criteria for HD(Hoarding disorder), 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups.
The average age of the 3 groups was HD: 43.9±11.5, OCD: 39.9±9.0, HCs: 42.4±10.4 respectively. In the results of VBM analyses, all three groups (HD, OCD, and HCs) exhibited the presence of significant regional GM volume differences in the right prefrontal regions.
As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD.

Free Research Field

精神病態医学