2017 Fiscal Year Final Research Report
The effects of cognitive remediation on the activatity of the reward systems in schizophrenia
| Project/Area Number |
15K09866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
PU Shenhong
ITAKURA Masashi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 統合失調症 / 認知機能障害 / 認知リハビリテーション / 動機付け / 報酬系 / fMRI |
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| Outline of Final Research Achievements |
We investigated the effects of NEAR, which is one method of cognitive remediation therapy, on motivational states of the participants assessed with "Quality of Life Scale (QLS)" and on functional connectivity between the pairs of brain regions within brain reward system measured with resting-state functional magnetic resonance imaging.
After three months of NEAR, the score of the "Motivation" item increased by 2.1 points compared with that assessed at baseline. On the other hand, NEAR did not affect functional connectivity between any pair of two brain regions within brain reward system. The finding that NEAR did not influence the functional connectivity may result from two factors: the contribution of the brain regions outside the reward system and methodological issues on defining region of interest within the brain reward system.
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| Free Research Field |
精神医学
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