Quantification and imaging of cerebral amyloid by quantitative susceptibility mapping

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K09896
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: University of Miyazaki
• Principal Investigator: Hirai Toshinori 宮崎大学, 医学部, 教授 (40274724)
• Co-Investigator(Kenkyū-buntansha): 橋本 衛 熊本大学, 大学院生命科学研究部(医), 准教授 (20452881) ; 池田 学 熊本大学, 大学院生命科学研究部(医), 客員教授 (60284395)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: MRI / アルツハイマー病 / 定量的磁化率マップ

Outline of Final Research Achievements

We studied 16 Alzheimer disease (AD) patients, 14 dementia with Lewy bodies (DLB) patients and 16 age- matched healthy controls (HC) using quantitative susceptibility mapping (QSM). The mean susceptibility values (MSVs) of the bilateral substantia nigra (SN), red nucleus (RN), caudate nucleus (CN), globus pallidus (GP), putamen (PT), substantia nigra (SN), hand motor area of precentral gyrus (PG), precuneus (PrCn) and cuneus (Cun) were measured on QSM images. Measurement differences were statistically assessed. The MSV of the SN was highest for AD, followed by DLB and HC, but no significant difference was observed. In the PrCn the MSV tended to be higher for AD and DLB than HC, but no significant difference was observed. There were no significant differences among the 3 groups in other structures. QSM might be useful for evaluating dementia patients. Further investigation with large population is needed to clarify the clinical role of QSM.

Free Research Field

放射線医学分野